Perception Processing in Schizophrenia Patients and Normal Population

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2011 by HaEmek Medical Center, Israel.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
HaEmek Medical Center, Israel
ClinicalTrials.gov Identifier:
NCT01298349
First received: December 2, 2010
Last updated: February 16, 2011
Last verified: February 2011
  Purpose

The present study aimed to examine face and object perception processes in schizophrenic patients. Schizophrenia is associated with deficits in visual processing that represent a key feature in the disorder. Previous studies have shown that schizophrenics exhibit deficits in a variety of facial-processing tasks (e.g., face recognition, recognition of facial expressions), that may severely hinder the patients' interpersonal and social skills. Some investigators have attributed these deficits to impairments in configural processing in schizophrenia. That is, an impairment in the ability to process the spatial relations between the constituent parts of a configuration (e.g., the spacing between the eyes of a given face). To date, studies aimed to investigate this possibility (e.g., Schwartz et al., 2002; Yong-Wook et al., 2008) yielded conflicting results. Additionally, it is not yet clear whether the hypothesized impairment in configural processing is restricted to faces, or whether it is more general in nature and applies to objects as well.


Condition
Schizophrenia
Normal Population

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Perception Processing in Schizophrenia Patients and Normal Population.

Resource links provided by NLM:


Further study details as provided by HaEmek Medical Center, Israel:

Primary Outcome Measures:
  • Performance in Experiment 1: Probability of Global Perception (%) [ Time Frame: 2 weeks. ] [ Designated as safety issue: No ]
    The probabilities (in percentage) of choosing the comparison figure having the same configuration as the standard figure. That is, the ratio between the number of trials in which participants chose the comparison figure as having the same configuration as the standard figure, and the total number of trials.

  • Performance in Experiment 2: Response Time (milliseconds) [ Time Frame: 2 weeks. ] [ Designated as safety issue: No ]
    Response Time in milliseconds; will be measured from stimulus onset on screen until prticipant's response.

  • Performance in Experiment 2: Error Rate (%) [ Time Frame: 2 weeks. ] [ Designated as safety issue: No ]
    Percentage of Errors; The ratio between number of errors and the total number of responses.


Estimated Enrollment: 200
Study Start Date: February 2011
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
schizophrenic patients
normal population

Detailed Description:

In the present study we investigate the relative contribution of component versus configural properties to face and object perception in schizophrenic and control subjects. To this end, we designed a series of experiments that are based on former work by Kimchi and Palmer (1982), and on my Ph.D. dissertation conducted under the supervision of Prof. Ruth Kimchi at the IIPDM.

Experiment 1 investigates the relative roles of local parts versus global configuration in object perception by applying a technique formalized by Kimchi and Palmer (1982). Participants are presented with hierarchical figures, in which larger figures (e.g., a "global" triangle) are constructed by smaller figures (e.g., "local" squares).

Participants (schizophrenics and controls) perform a similarity-judgment task. In each experimental trial, participants are presented with a triad of stimuli: a standard figure and two comparison figures. Participants are asked to determine which of the two comparison figures is more similar to the standard. Each figure consists of a global square or triangle made of local squares or triangles. In the "same configuration" comparison figure different elements are arranged in the same configuration as the standard figure. In the "same element" comparison figure, the same elements as in the standard figure are used, but are arranged in a different configuration. The number of elements used to construct the standard figure is varied. Previous data with normal perceivers (Kimchi & Palmer, 1982) showed that as the number of elements increased (and their sizes decreased) perceivers tended to base their similarity judgments on the global configuration, rather than on its local elements. If schizophrenics are impaired in their ability to process configural information then their similarity judgments should mainly rely on the local elements rather than on the global configuration.

Experiment 2 examines the relative contribution of facial components (e.g., eyes, nose, mouth) versus configural properties (e.g., spacing between the eyes) to face perception, by applying Garner's speeded classification paradigm (Garner, 1974). We have previously applied this paradigm in my Ph.D. dissertation to study face perception in normal perceivers.

The stimulus set consists of four faces created by orthogonally combining components (eyes, nose, and mouth) and configural information (inter-eyes distance and nose-mouth distance). On each trial participants are asked to classify a face on either its components or its configural information, in two conditions. In the control condition only one facial dimension varies (e.g., components) while the other dimension (e.g., configural information) is held constant. In the filtering condition the two dimensions are varied orthogonally. Equal performance in the control and filtering conditions indicates that participants are able to selectively attend to the relevant dimension - the dimensions are processed independently. Poorer performance in the filtering condition than in the control condition - Garner interference - indicates that it is not possible to selectively attend to one dimension while ignoring another, irrelevant dimension - the dimensions are processed interactively.

Results with normal perceivers revealed a symmetric Garner interference with upright faces: participants were unable to selectively attend to components and ignore irrelevant variation in configural information, and vice versa. These results imply perceptual interdependence in processing components and configural information. If schizophrenics are impaired in their ability to process configural information then patients should be able to selectively attend to components and ignore irrelevant variation in configural information, but not vice versa. This pattern would indicate the relative dominance of components over configural properties in upright face processing of schizophrenia patients.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

patients diagnosed with schizophrenia or schizo-affective disorder according to DSM4 and normal population with no psychiatric history

Criteria

Inclusion Criteria:

  • schizophrenia or schizo-affective disorder
  • normal population with no psychiatric history
  • Stable medication for at least a month before participating in the study
  • subjects must have normal vision or revised

Exclusion Criteria:

  • deterioration of the disorder
  • subject will
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01298349

Contacts
Contact: Boaz Bloch, MD +97246494351 bloch_bo@clalit.org.il

Locations
Israel
Haemek Medical Center Not yet recruiting
Afula, Israel
Sponsors and Collaborators
HaEmek Medical Center, Israel
Investigators
Principal Investigator: Boaz Bloch, MD Haemek Mediacl Center
Study Chair: Alon Reshef, MD Haemek Medical Center
Study Chair: Rama Amishav, Phd Haemek Medical Center
  More Information

No publications provided

Responsible Party: Boaz Bloch, HaEmek Medical Center, Israel
ClinicalTrials.gov Identifier: NCT01298349     History of Changes
Other Study ID Numbers: 104-10
Study First Received: December 2, 2010
Last Updated: February 16, 2011
Health Authority: Israel: Ethics Commission

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on August 21, 2014