The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis
Recruitment status was Recruiting
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the inflammatory process occuring in the sinuses.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||New Insights on the Clinical Significance of the Uncinate Process Histopathology in Patients With Chronic Rhinosinusitis|
Pathologic uncinate process tissue
|Study Start Date:||March 2010|
|Estimated Study Completion Date:||December 2011|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
Adult patients with chronic rhinosinusitis who failed treatment with antibiotics and topical corticosteroids and underwent endoscopic sinus surgery. Preoperative evaluation included paranasal sinus CT scans. The diagnosis was confirmed by endoscopic examination showing purulent and/or mucopurulent discharge in the middle and/or superior meatus.
The purpose of the present study is to gain insight into the histopathological changes of the uncinate process in patients with chronic rhinosinusitis through comparison of its mucosal and bony elements with those of the normal uncinate process without chronic inflammation (unpublished data: Gilead Berger, Ephraim Eviatar, Tatiana Kogan, Roee Landsberg).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01296919
|Tel Aviv, Israel|
|Contact: Eitan Yaniv, MD 052-2509890 firstname.lastname@example.org|
|Contact: Roee Landsberg, MD 052-4266359|
|Principal Investigator:||Gilead Berger, MD||AssutaHS, Meir Medical Center|
|Study Chair:||Eitan Yaniv, MD||Assuta Hospital Systems|
|Study Director:||Roee Landsberg, MD||Assuta Hospital Systems|