Interaction Effect of Asthma and Aeroallergen Category on the Psychological Status in Allergic Rhinitis Patients

This study has been completed.
Sponsor:
Information provided by:
Beijing Tongren Hospital
ClinicalTrials.gov Identifier:
NCT01295255
First received: February 11, 2011
Last updated: NA
Last verified: January 2011
History: No changes posted
  Purpose

Allergic rhinitis (AR) and asthma are considered as "one airway, one disease". Although there is increasing evidence for an association between allergy and depression, it remains unknown if the relationship between AR and asthma has extra influence on the psychological status of the patients. The aim of our study was to investigate the influence pattern of asthma on the psychological status in AR patients. The Symptom Checklist-90 (SCL-90) was employed to analyze the psychological status of 524 individuals with AR. Independent sample T-tests, one-way ANOVA and multivariate ANOVA were used for data analyses.


Condition
Hypersensitivity
Psychologic Factors in Physical Conditions Classified Elsewhere
Respiratory Tract Diseases
Allergic Rhinitis

Study Type: Observational
Study Design: Observational Model: Cohort

Resource links provided by NLM:


Further study details as provided by Beijing Tongren Hospital:

Enrollment: 524
Study Start Date: February 2009
Study Completion Date: November 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   16 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

524 affected individuals (311 males and 213 females) with AR were prospectively recruited from the rhinology clinic of the Otolaryngology, Head and Neck Surgery Department of Beijing Tongren Hospital from February 2009 to November 2009.

Criteria

Inclusion Criteria:

  • Patients suffered from rhinitis symptoms such as nasal itching, sneezing, nasal obstruction and running nose, all patients had not undergone any medicine therapy in the past one week; nasal endoscopy showed a pale and edematous nasal mucosa, nasal discharge and swollen inferior turbinates. Every nasal symptom was scored on Visual analog scale (VAS, 0-3 score) respectively. A score of 0 indicated no nasal symptom, 1 indicated slight nasal symptoms, 2 indicated obvious nasal symptom, but which could still be endured, and 3 indicated obvious nasal symptoms that could not be endured;
  • Age between 16 to 60 years;
  • A positive skin prick test (SPT)to at least one allergen, the level of response equal to or exceeding ++. The following inhalant allergens were tested: Der p; Der f; Animal hair; Trees; Grasses; Cereals; Mugwort; Dandelion; Giant ragweed; Chenopodium album; Humulus; Locust; Blatella germanica; Pine; Plantain; Curvularia lunata; Candida albicans; Penicillium notatum; Alternaria tenuis and Aspergillus fumigatu. The reactions were evaluated based on the mean wheal diameter at 15 minutes after application of the extracts. The mean diameters of each allergen wheals were calculated from the sum of the largest measurement across the wheal and the largest wheal measurement perpendicular to this divided by two. In addition, we calculated the skin index (SI) as the ratio of allergen weal diameter divided by the histamine weal size. The SPT result for each allergen was defined in terms of the SI value as follows: +: SI≤0.5; ++: 0.5<SI≤1.0; +++: 1.0<SI≤2.0; ++++: SI>2.0.

Exclusion Criteria:

  • AR combined with hypertension, diabetes or other chronic diseases;
  • AR combined with tumor in the nasal cavity;
  • AR combined with eczema;
  • Acute infection in the past one week;
  • Failure to complete the questionnaires;
  • AR patients undergoing negative life events.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01295255

Sponsors and Collaborators
Beijing Tongren Hospital
Investigators
Principal Investigator: DeMin Han, Phd Beijing Tongren Hospital
  More Information

No publications provided

Responsible Party: Demin Han, Beijing Tongren Hospital
ClinicalTrials.gov Identifier: NCT01295255     History of Changes
Other Study ID Numbers: 1130
Study First Received: February 11, 2011
Last Updated: February 11, 2011
Health Authority: China: Beijing Municipal Science and Technology Commission

Keywords provided by Beijing Tongren Hospital:
Allergic rhinitis
Psychological status
Asthma
Aeroallergen

Additional relevant MeSH terms:
Hypersensitivity
Respiratory Tract Diseases
Rhinitis
Immune System Diseases
Nose Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases

ClinicalTrials.gov processed this record on July 28, 2014