Serum Magnesium and Vascular Calcification
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Purpose
Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium.
| Condition |
|---|
|
Vascular Calcification Chronic Kidney Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Comparison of Vascular Calcification Between Kidney Transplant Recipients and Predialysis Chronic Kidney Disease and Its Association With Serum Magnesium |
- The difference in vascular calcification score between KT and CKD [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- The association of serum magnesium with vascular calcification in KT [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- The association of serum magnesium with vascular calcification in CKD [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
serum
| Estimated Enrollment: | 400 |
| Study Start Date: | February 2011 |
| Study Completion Date: | May 2011 |
| Primary Completion Date: | May 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Kidney transplant recipients |
| Chronic kidney disease |
Detailed Description:
Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Kidney transplant recipients and predialysis chronic kidney disease patients from outpatient nephrology clinic of Ramathibodi hospital, Mahidol University
Inclusion Criteria:
- kidney transplant recipients at least 1 year post surgery
- predialysis chronic kidney disease with serum creatinine > 1.1 mg/dL in female and 1.3 mg/dL in male
Exclusion Criteria:
- acute kidney injury
- parathyroidectomy
Contacts and Locations| Thailand | |
| Faculty of Medicine, Ramathibodi Hospital, Mahidol University | |
| Phayathai, Bangkok, Thailand, 10400 | |
| Principal Investigator: | Sinee Disthabanchong, MD | Ramathibodi Hospital, Mahidol University |
More Information
No publications provided
| Responsible Party: | Sinee Disthabanchong, MD, Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand |
| ClinicalTrials.gov Identifier: | NCT01293786 History of Changes |
| Other Study ID Numbers: | 03-02-2011 |
| Study First Received: | February 10, 2011 |
| Last Updated: | May 25, 2011 |
| Health Authority: | Thailand: Mahidol University |
Keywords provided by Ramathibodi Hospital:
|
magnesium kidney transplantation hypomagnesemia |
Additional relevant MeSH terms:
|
Calcinosis Kidney Diseases Renal Insufficiency, Chronic Kidney Failure, Chronic |
Calcium Metabolism Disorders Metabolic Diseases Urologic Diseases Renal Insufficiency |
ClinicalTrials.gov processed this record on May 23, 2013