The Impact of Early Embryos Incubation on Pregnancy Rate in IVF (IVF-2010)
Frozen- thawed embryos obtained by IVF treatments are transferred to the uterus immediately following thawing or after incubation for additional 24-72 hours. The two methods are routine in IVF laboratories. In this study the investigators would like to compare between these two methods in terms of implantation rate, pregnancy rate and delivery.
In Vitro Fertilization
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Impact of Early Embryos Incubation on Pregnancy Rate in IVF|
- Pregnancy as measured by blood test for beta hCG [ Time Frame: 12 days following embryos transfer ] [ Designated as safety issue: Yes ]as the usual routine, the women come on day 12 or 13 following embryo transfer to pur IVF unit to get blood teat for beta hCG. When the result show that the beta hCG is above 5 unit/liter we consider it as positive result and the patients is invited for additional blood test 2 days later/
- Delivery of baby [ Time Frame: 9 mounth after embryos transfer ] [ Designated as safety issue: Yes ]We are routinely report to the Israeli ministry of health all the children who were born from our treatment. In this study we will calculate the number of children per thawed embryo transfer.
|Study Start Date:||April 2011|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
Transfer at the day of embryo thawing
Transfer of thawed embryos 24-72 hours post thawing
It has been common practice to cryopreserve surplus embryos achieved during IVF treatment or in other situation that embryos are to be preserved for other situations such as suspected ovarian hyper stimulation syndrome, fertility preservation or patient request.
Embryos are usually frozen on day 2, 3 or day 5-6 at the Blastocyst stage. At the time that thawing is planned, patients' cycle is synchronized and prepared either with hormonal treatment or at the natural cycle.
Not all embryos will always survive the thawing and sometimes they will all degenerate.
Embryos that survive the thawing procedure are assessed and replaced on the day of the thaw or left overnight for better selection and will be replaced only if they continue to divide in vitro.
The advantage of embryo transfer on the day of thaw is that embryo exposure in culture is shortened and embryo selection will be occurring in the womb. On the other hand, overnight incubation may avoid transferring embryos that potentially are not able to divide and are biologically not viable.
Although both attitudes are practiced in different IVF centers, at present there are no prospective randomized studies that have been conducted to advise which intervention is better in terms of pregnancy rates.
The purpose of the present study is to assess which technique will result in better pregnancy rates.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01287273
|Contact: Martha Dirnfeld, MD||8250335 ext firstname.lastname@example.org|
|Contact: Shirly Lahav-Baratz, D.Sc||8250118 ext email@example.com|
|Carmel Medical Center||Recruiting|
|Haifa, Israel, 34362|
|Contact: Martha Dirnfeld, MD 8250335 ext 9724 firstname.lastname@example.org|
|Contact: Shirly Lahav-Baratz, D.Sc 8250118 ext 9724 email@example.com|
|Principal Investigator: Martha Dirnfeld, MD|
|Principal Investigator:||Martha Dirnfeld, MD||Carmel Medical Center IVF Unit|