Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination
Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
|Official Title:||Immune Response After Booster Vaccination in HIV - Infected Patients Who Ever Received Rabies Primary Vaccination|
- Rabies Neutralizing Antibody Titers [ Time Frame: Day 360 ] [ Designated as safety issue: No ]
Rabies Neutralizing Antibody titers(RNab)of HIV-infected patients who receive booster rabies vaccination would be measured by Rapid Fluorescent Focus Inhibition Test(RFFIT) method at day 0, 7, 14, 28, 90,180 and 360. RNab level above 0.5 IU/ml indicate acceptable protective antibody response.
for 7 times in 1 year.
|Study Start Date:||February 2011|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
Experimental: Rabies vaccines on day 0 and 3
Cell culture Rabies vaccines on day 0 and 3
Biological: rabies vaccines on day 0 and 3
All subjects would receive conventional intramuscular booster rabies vaccination on day 0 and 3. Their blood would be drawn for rabies neutralizing antibody on day 0,7,14,30,90,180,360
The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01286493
|Queen Saovabha Memorial Institute|
|Bangkok, Thailand, 10330|
|Principal Investigator:||Suda Sibunruang, MD||Queen Saovabha Memorial Institute|