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Natural History of Chronic Urticaria (NHCU)

This study has been completed.
Information provided by (Responsible Party):
Orathai Piboonpocanun, Mahidol University Identifier:
First received: January 20, 2011
Last updated: September 8, 2014
Last verified: September 2014

The purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.

Chronic Urticaria

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Natural History of Chronic Urticaria in Childhood: A Prospective Study

Resource links provided by NLM:

Further study details as provided by Mahidol University:

Primary Outcome Measures:
  • Duration of urticaria until remission since chronic urticaria was diagnosed. [ Time Frame: 1-10 years ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Variable factors contributed the shorter duration of chronic urticaria. [ Time Frame: 1-10 years ] [ Designated as safety issue: Yes ]

Enrollment: 94
Study Start Date: March 2003
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Chronic urticaria
Chronic urticaria, Natural history

Detailed Description:

A Prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.


Ages Eligible for Study:   4 Years to 15 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, Children 4-15 years of age with chronic urticaria.


Inclusion Criteria:

  • Children 4-15 years of age with the diagnosis of chronic urticaria who were attending the pediatric allergy clinic, Siriraj Hospital Mahidol University, Thailand, from March 2003 to March 2009.

Exclusion Criteria:

  • Children who had isolated physical urticaria, inability to be followed up, pregnancy, underlying diseases such as cardiovascular, hepatobiliary, and renal diseases.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01284426

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700
Sponsors and Collaborators
Mahidol University
Principal Investigator: Orathai Piboonpocanun, Prof. Siriraj Hospital, Mahidol University
  More Information

Responsible Party: Orathai Piboonpocanun, Prof., Mahidol University Identifier: NCT01284426     History of Changes
Other Study ID Numbers: 374/2551(EC3)
Study First Received: January 20, 2011
Last Updated: September 8, 2014
Health Authority: Thailand: Ethical Committee

Keywords provided by Mahidol University:
Chronic urticaria
Natural course

Additional relevant MeSH terms:
Hypersensitivity, Immediate
Immune System Diseases
Skin Diseases
Skin Diseases, Vascular processed this record on November 25, 2014