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Renal Tubular Acidosis in Incident Renal Transplant Recipients

This study is currently recruiting participants.
Verified January 2011 by Universitaire Ziekenhuizen Leuven
Sponsor:
Information provided by (Responsible Party):
Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
NCT01283880
First received: January 25, 2011
Last updated: May 29, 2012
Last verified: January 2011
History of Changes
  Purpose

Metabolic acidosis is a common complication in incident renal transplant recipients. Protracted acidosis may be associated with osteoporosis, inflammation, negative protein balance and malnutrition, and last but not least may cause renal dysfunction. Preliminary data indicate an increased prevalence of nephrocalcinosis in renal transplant biopsies of incident patients presenting with metabolic acidosis. The present study aims (1)evaluate the prevalence and type of renal tubular acidosis (RTA) in incident renal transplant recipients and to identify clinical correlates and (2) to find associations between RTA, nephrolithiasis and nephrocalcinosis


Condition
Renal Transplant Disorder

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Renal Tubular Acidosis in Incident Renal Transplant Recipients

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Universitaire Ziekenhuizen Leuven:

Estimated Enrollment: 50
Study Start Date: May 2012
Estimated Study Completion Date: June 2013
Estimated Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

renal transplant recipients

Criteria

Inclusion Criteria:

  • Recipient of a single kidney transplant included in the protocol biopsy program.
  • eGFR > 30 ml/min
  • Age ≥ 18 years
  • Written informed consent

Exclusion Criteria:

  • none
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01283880

Contacts
Contact: Pieter Evenepoel, MD 003216344580 pieter.evenepoel@uz.kuleuven.ac.be

Locations
Belgium
University Hospitals Leuven Recruiting
Leuven, Belgium, 3000
Principal Investigator: Pieter Evenepoel, MD            
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Investigators
Principal Investigator: Pieter Evenepoel, MD University Hospitals Leuven
  More Information

No publications provided

Responsible Party: Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier: NCT01283880     History of Changes
Other Study ID Numbers: ML6919
Study First Received: January 25, 2011
Last Updated: May 29, 2012
Health Authority: Belgium: University Hospitals Leuven

Keywords provided by Universitaire Ziekenhuizen Leuven:
kidney
transplantation
metabolic acidosis
renal tubular acidosis
nephrocalcinosis

Additional relevant MeSH terms:
Acidosis
Acidosis, Renal Tubular
Acid-Base Imbalance
Metabolic Diseases
Renal Tubular Transport, Inborn Errors
 Kidney Diseases
Urologic Diseases
Metabolism, Inborn Errors
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on May 19, 2013