Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Requiring General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on the Cardiovascular System in Common Clinical Practice (SEVOPROTECTION)

• Time to Loss of Consciousness of Patients Administered Anesthesia [ Time Frame: Up to 16 minutes ] [ Designated as safety issue: No ]
  Loss of consciousness was measured from the time the anesthetic was administered until loss of consciousness (loss of eyelash reflex) occurred.
  
  
• Time to Awakening of Patients [ Time Frame: Every minute after anesthesia was stopped until the patient responded to a verbal command ] [ Designated as safety issue: No ]
  Measured from the time anesthesia administration was stopped until the patient responded to a verbal command.
  
  
• Time to Extubation of Patients [ Time Frame: Every minute after anesthesia was stopped until extubation occurred ] [ Designated as safety issue: No ]
  Time to extubation was measured from the time anesthesia administration was stopped until tracheal extubation occurred.
  
  
• Anesthesiologists' Satisfaction With Using Sevorane for Induction and Maintenance Anesthesia [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
  The anesthesiologist's overall satisfaction with the inhalation anesthesia with Sevorane for each patient was assessed by means of a numerical rating scale ranging from 0 (dissatisfied) to 10 (very satisfied).
  
  
• Patients' Overall Impression of the Anesthesia With Sevorane [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
  After awakening from anesthesia, patients were surveyed regarding their overall impression of anesthesia with Sevorane. Patients selected one of the following answers: excellent, positive, indifferent, or other.
  
  

• Systolic Blood Pressure [ Time Frame: Before starting anesthesia to one hour after the operation ] [ Designated as safety issue: No ]
  The systolic blood pressure of each patient was recorded at different time points from just before the start of anesthesia to one hour after the operation concluded.
  
  
• Diastolic Blood Pressure [ Time Frame: Before starting anesthesia to one hour after the operation ] [ Designated as safety issue: No ]
  The diastolic blood pressure of each patient was recorded at different time points from just before the start of anesthesia to one hour after the operation concluded.
  
  
• Mean Arterial Pressure [ Time Frame: Before starting anesthesia to one hour after the operation ] [ Designated as safety issue: No ]
  The mean arterial pressure of each patient was recorded at different time points from just before the start of anesthesia to one hour after the operation concluded.
  
  
• Heart Rate [ Time Frame: Before starting anesthesia to one hour after the operation ] [ Designated as safety issue: No ]
  The heart rate of each patient was recorded at different time points from just before the start of anesthesia to one hour after the operation concluded.
  
  
• Presence of Deviations in Electrocardiogram Assessments During Anesthesia [ Time Frame: During induction and maintenance of anesthesia on Day 1 ] [ Designated as safety issue: No ]
  Electrocardiogram (ECG) assessments performed during induction of the anesthesia and maintenance were analyzed with respect to the presence of the following deviations: blockades (problems with heart electrical activity), extrasystoles (extra abnormal heart beats), arrhythmia (abnormal heart rate or rhythm), and myocardial ischemia (decreased blood flow to the heart).
  
  
• Cardiac Troponin (Troponin T) (if Available) [ Time Frame: Within 24 hours after anesthesia ] [ Designated as safety issue: No ]
  Troponin T values measured within 24 hours of anesthesia were to be collected when available. No data were reported for this outcome measure during the study.
  
  
• Creatine Kinase Myocardial Isoenzyme (if Available) [ Time Frame: Within 24 hours after anesthesia ] [ Designated as safety issue: No ]
  Creatine kinase myocardial isoenzyme (CK-MB) values measured within 24 hours of anesthesia were to be collected when available.
  
  
• Correlation Between Anesthesiologists' Clinical Experience and Hemodynamic Parameters During Anesthesia [ Time Frame: Before starting anesthesia to one hour after the operation ] [ Designated as safety issue: No ]
  The anesthesiologists' length of clinical experience with Sevorane was collected. The influence of this experience on the changes in hemodynamic parameters during anesthesia with Sevorane was evaluated by calculating Spearman's correlation coefficient between the duration of clinical experience with Sevorane and the changes in blood pressure, mean arterial pressure, and heart rate between T0 (before anesthesia) and T1 (at the end of induction), T2 (at the end of surgical incision), T3 (at the end of extubation), T4 (1 hour after the operation), and the minimum and maximum values, respectively.
  
  
• Correlation Between Anesthesiologists' Clinical Experience and Time to Extubation and Awakening [ Time Frame: Every minute after anesthesia was stopped until the patient was extubated and until the patient responded to a verbal command. ] [ Designated as safety issue: No ]
  Anesthesiologists' length of clinical experience with general anesthesia and modern inhalation agents was collected. The influence of this clinical experience on anesthesia parameters was evaluated by calculating Spearman's correlation coefficient between the duration of clinical experience (exp) with inhalation (inh) anesthesia and Sevorane on the time to extubation and the time to awakening, respectively.
  
  

This PMOS will be conducted in a prospective, multi-centre format. It is a non-interventional, observational study in which Sevorane is prescribed for adult patients undergoing general surgery for induction and maintenance of anesthesia in the usual manner in accordance with the terms of the local marketing authorization. Sevorane is used for induction and maintenance anesthesia by the choice of anesthesiologist. No additional procedures (other than standard of care) shall be applied to the patients. Each patient will be observed from the starting of anesthesia till the anesthesia end. Markers of myocardial ischemia will be detected up to the first 24 hours after anesthesia (if available). Additionally the correlation between the experience and training background of anesthesiologists and patient related outcomes of general anesthesia with sevoflurane as a single anesthetic will be assessed.