Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Recruitment status was Recruiting
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Purpose
The purpose of this study is to
- Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
- Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.
| Condition |
|---|
|
Compression Fracture of Thoracic Vertebral Body Spinal Compression Fracture |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures |
| Estimated Enrollment: | 70 |
| Study Start Date: | January 2011 |
| Estimated Study Completion Date: | December 2011 |
| Estimated Primary Completion Date: | December 2011 (Final data collection date for primary outcome measure) |
Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).
The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.
MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.
Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.
Eligibility| Ages Eligible for Study: | 18 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients are recruited from Department of Orthopedics between january 2011 and december 2011.
Inclusion Criteria:
- Compression fractures (thoracic and lumbar vertebrae)
Exclusion Criteria:
- Age less than 18 years
- Pregnancy
- Any contraindications to MR imaging.
Contacts and Locations| Contact: Chien-Kuo Wang | 886-6-2353535 ext 2491 | n044206@mail.hosp.ncku.edu.tw |
| Taiwan | |
| National Cheng-Kung University Hospital | Recruiting |
| Tainan, Taiwan | |
| Contact: Chien-Kuo Wang 886-6-2353535 ext 2491 n044206@mail.hosp.ncku.edu.tw | |
| Study Chair: | Chien-Kuo Wang | Department of Diagnostic Radiology Cheng Kung University Medicial Center |
More Information
No publications provided
| Responsible Party: | Chien-Kuo Wang/Department of Diagnostic Radiology, National Cheng-Kung University Hospital |
| ClinicalTrials.gov Identifier: | NCT01281826 History of Changes |
| Other Study ID Numbers: | BR-99-093 |
| Study First Received: | January 20, 2011 |
| Last Updated: | February 9, 2011 |
| Health Authority: | Taiwan: Institutional Review Board |
Additional relevant MeSH terms:
|
Fractures, Bone Fractures, Compression Wounds and Injuries |
ClinicalTrials.gov processed this record on May 23, 2013