Impact of Genetic Polymorphisms on Dental Implant Loss
This study is currently recruiting participants.
Verified February 2013 by University Hospital, Ghent
Sponsor:
University Hospital, Ghent
Information provided by (Responsible Party):
University Hospital, Ghent
ClinicalTrials.gov Identifier:
NCT01274442
First received: January 10, 2011
Last updated: February 1, 2013
Last verified: February 2013
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Purpose
Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007.
According to one of our recent papers based on this patient group, 34/461 patients lost one or more implants. The goal is to invite these 34 patients, to update the anamnesis, to perform a brief clinical oral examination and to have a blood sample. The latter is necessary to identify relevant genetic polymorphisms of the patient that are associated with implant loss. Among the remaining patients that did not lose implants, another 34 'controls' will be invited for the same examinations.
| Condition | Intervention |
|---|---|
|
Patients Treated by Means of 1 or More Dental Implants |
Other: anamnesis Procedure: oral examination Procedure: Blood sample |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Diagnostic |
| Official Title: | A Case-control Study on the Impact of Genetic Polymorphisms on Dental Implant Loss. |
Further study details as provided by University Hospital, Ghent:
Primary Outcome Measures:
- genetic polymorphisms associated with implant loss [ Time Frame: after 3 to 6 years ] [ Designated as safety issue: No ]Identification of genetic polymorphisms that are associated with implant loss. It concerns only one evaluation (1 blood sample).
| Estimated Enrollment: | 68 |
| Study Start Date: | June 2011 |
| Estimated Study Completion Date: | March 2013 |
| Estimated Primary Completion Date: | March 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: CONTROL: no dental implants lost
Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
|
Other: anamnesis
To update the anamnesis.
Procedure: oral examination
A brief clinical oral examination will be performed.
Procedure: Blood sample
A blood sample will be taken to identify relevant genetic polymorphisms.
|
|
Experimental: CASE: patients lost one or more implants
Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.
|
Other: anamnesis
To update the anamnesis.
Procedure: oral examination
A brief clinical oral examination will be performed.
Procedure: Blood sample
A blood sample will be taken to identify relevant genetic polymorphisms.
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Dental implant surgery in the University Hospital in Ghent in 2004-2007.
- Case: dental implant loss
- Control: no dental implant loss
Exclusion Criteria:
-
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01274442
Contacts
| Contact: Elisabeth De Wilde, Dentist | Elisabeth.DeWilde@ugent.be |
Locations
| Belgium | |
| University Hospital Ghent | Recruiting |
| Ghent, Belgium, 9000 | |
| Contact: Elisabeth De Wilde, Dentist Elisabeth.DeWilde@ugent.be | |
| Principal Investigator: Hugo De Bruyn, MD, PhD | |
Sponsors and Collaborators
University Hospital, Ghent
Investigators
| Principal Investigator: | Hugo De Bruyn, MD, PhD | University Hospital, Ghent |
More Information
Additional Information:
No publications provided
| Responsible Party: | University Hospital, Ghent |
| ClinicalTrials.gov Identifier: | NCT01274442 History of Changes |
| Other Study ID Numbers: | 2010/771 |
| Study First Received: | January 10, 2011 |
| Last Updated: | February 1, 2013 |
| Health Authority: | Belgium: Ethics Committee |
Keywords provided by University Hospital, Ghent:
|
dental implant |
ClinicalTrials.gov processed this record on May 23, 2013