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Cognitive Stimulation

This study is currently recruiting participants.
Verified November 2012 by Johns Hopkins University
Sponsor:
Collaborator:
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
Miriam Mintzer, Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT01271413
First received: January 5, 2011
Last updated: November 30, 2012
Last verified: November 2012
History of Changes
  Purpose

This research is being done to learn if computer tasks that challenge the brain (cognitively stimulating tasks) can improve memory and other types of thinking. The study will compare the effects of different versions of the computer tasks. It also will compare the task performance of different groups of people.


Condition Intervention Phase
Substance Use Disorders
 Behavioral: Computerized cognitively stimulating activities
 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Cognitive Training in Methadone Maintenance Patients

Resource links provided by NLM:

MedlinePlus related topics: Memory
U.S. FDA Resources

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • working memory [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • episodic memory [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]
  • trail-making [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]
  • go/no-go [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]
  • Addiction Severity Index [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]
  • delay discounting [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]
  • Digit Symbol Substitution Test [ Time Frame: baseline, post-training ] [ Designated as safety issue: No ]

Estimated Enrollment: 90
Study Start Date: December 2010
Estimated Study Completion Date: August 2013
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitively Stimulating Activities Behavioral: Computerized cognitively stimulating activities
The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.
Active Comparator: Cognitively stimulating activities: Other Behavioral: Computerized cognitively stimulating activities
The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.
Active Comparator: Healthy volunteers Behavioral: Computerized cognitively stimulating activities
The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 18-55
  • in methadone maintenance or healthy volunteers
  • healthy

Exclusion Criteria:

  • Axis I disorder (except substance abuse and dependence in methadone maintenance patients)
  • severe cognitive impairment
  • serious untreated medical condition
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01271413

Contacts
Contact: Katherine Buckheit, BA (410) 550-1465 kbuckhe1@jhu.edu

Locations
United States, Maryland
BPRU, Johns Hopkins Bayview Medical Center Recruiting
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
National Institute on Drug Abuse (NIDA)
Investigators
Principal Investigator: Miriam Z Mintzer, PhD Johns Hopkins University
  More Information

No publications provided

Responsible Party: Miriam Mintzer, Associate Professor, Johns Hopkins University
ClinicalTrials.gov Identifier: NCT01271413     History of Changes
Other Study ID Numbers: NA_00042772, 1R21DA029708
Study First Received: January 5, 2011
Last Updated: November 30, 2012
Health Authority: United States: Federal Government
United States: Institutional Review Board

Additional relevant MeSH terms:
Substance-Related Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 22, 2013