Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
Recruitment status was Recruiting
This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults. Participants will engage in 3 months of exercise 3-5 times per week using a chair and small weights. It is hypothesized that there will be a significant improvement in brain function.
Mild Cognitive Impairment
Behavioral: strengthening exercises
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Neuropsychological and Neuroimaging Effects of Strengthening Exercise for Early Dementia and Normative Older Adults|
- Neuropsychological Function [ Time Frame: 3 months ] [ Designated as safety issue: No ]Cognitive function, especially executive functions, assessed with standardized pencil and paper tests.
- Neurophysiological Function [ Time Frame: 3 months ] [ Designated as safety issue: No ]This will be assessed using EEG recordings.
- Biomarker [ Time Frame: 3 months ] [ Designated as safety issue: No ]Brain-Derived Neurotrophic Factor (BDNF) will be assessed from periodic saliva samples.
|Study Start Date:||December 2010|
|Estimated Study Completion Date:||April 2011|
|Estimated Primary Completion Date:||April 2011 (Final data collection date for primary outcome measure)|
|Experimental: strengthening exercise||
Behavioral: strengthening exercises
3 months of 3-5 times per week of low-intensity exercises using a chair and small weights
Other Name: Strong Bones Program
- Objective(s): This study will evaluate the neuropsychological and neurophysiological effects of low-intensity strengthening exercise for patients with early dementia, compared with normative older adults.
- Research Design: This is a quasi-experimental design in which change over time as a result of the exercise intervention will be compared with change over time seen in a normative sample.
- Methodology: The aim is to enroll 12 participants with early dementia and 12 normative controls, all who are interested in starting a strengthening exercise program. Neuropsychological evaluation, EEG neuroimaging, and biomarker data collection will commence prior to the start of exercise. Participants will participate in an exercise class 2-3x/wk for three months. Repeat neuropsychological, EEG, and biomarker evaluations will occur at the conclusion of three months of exercise. The exercises consist of low-intensity exercises, using a chair and small weights. A leader trained in the Tufts University exercise model will conduct the classes.
- Findings: The investigators hypothesize a positive impact of exercise on neuropsychological function, especially performance on tasks requiring executive functions. This change will be compared with performance of normative controls who also exercise. Changes in brain function will be explored using EEG and biomarkers (e.g., BDNF), and results are expected to be similar to prior research examining older adult exercisers which shows improvement in function.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01264614
|Contact: Cay Anderson-Hanley, PhDemail@example.com|
|Contact: Mina Dunnam, PhDfirstname.lastname@example.org|
|United States, New York|
|Stratton VA Medical Center||Recruiting|
|Albany, New York, United States, 12208|
|Contact: Mina Dunnam, PhD 518-626-5396 email@example.com|
|Contact: Cay Anderson-Hanley, PhD 518-388-6430 firstname.lastname@example.org|
|Principal Investigator: Cay Anderson-Hanley, PhD|
|Principal Investigator: Mina Dunnam, PhD|
|Principal Investigator:||Cay Anderson-Hanley, PhD||Union College|