Veliparib and Radiation Therapy in Treating Patients With Advanced Solid Malignancies With Peritoneal Carcinomatosis

Inclusion Criteria:

• Patients must have histologically proven solid malignancy that is metastatic or unresectable with metastatic peritoneal carcinomatosis; as this entity may be difficult to image, peritoneal disease can be documented through other modalities such as operative notes, clinical notes/symptoms, etc as well as imaging
• Patients must be refractory to standard therapy or have no acceptable standard treatment options
• Eastern Cooperative Oncology Group (ECOG) performance status =< 1
• Life expectancy of greater than 3 months
• Absolute neutrophil count (ANC) >= 1,500/mcL
• Platelets >= 100,000/mcL
• Total bilirubin =< 1.5 X upper limit of normal (ULN)
• Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) =< 2.5 X ULN
• Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
• Magnesium >= lower limit of normal (LLN)
• Calcium within normal limit (WNL)
• No surgery, hormonal therapy or chemotherapy within four weeks
• No previous abdominal radiation; if the patient has received previous pelvic radiation there should not be any overlap between the current and previous radiation fields
• Toxicities of prior chemotherapy recovered to grade 1 or less except for stable grade 2 peripheral neuropathy
• Negative pregnancy test if premenopausal; women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
• Archival tumor sample collection with a tumor block is required for all enrolled patients when available; if no block can be released per institutional policy, 10 to 20 unstained slides may be substituted; slides should have a positive charge and a thickness of 3 to 5 microns; if the only tissue sample available is a fine needle aspirate (FNA), the patient will still be considered eligible
• Patients with central nervous system (CNS) metastases to be stable after therapy for > 3 months and off steroid treatment prior to study enrollment

Exclusion Criteria:

• Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
• Patients who are currently receiving any other investigational agents
• Brain metastases: patients with treated and stable brain metastasis for 3 months, off steroids will be eligible
• Patients who demonstrate any clinical evidence of bleeding
• Patients who have demonstrated an inability to swallow oral medications
• Patients who have had a documented malignant bowel obstruction (unless patient had obstruction as their presenting symptom)
• Patients who have a known hypersensitivity to the components of the study drug, its analogs or drugs of a similar chemical or biologic composition
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with veliparib; potential risks may also apply to other agents used in this study
• Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
• Patients who have uncontrolled ascites
• Patients with active seizures or a history of seizure are not eligible
• Patients previously treated with poly (ADP-ribose) polymerase 1 (PARP) inhibitors