Investigation of Human Alpha-fetoprotein Genes
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Purpose
Studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, this study will recruit the patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed.
| Condition |
|---|
|
Elevated or Normal Alpha-fetoprotein Patients |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Investigation of Human Alpha-fetoprotein Genes |
10c.c Whole Blood
| Estimated Enrollment: | 300 |
| Study Start Date: | December 2010 |
| Estimated Study Completion Date: | October 2013 |
| Estimated Primary Completion Date: | October 2013 (Final data collection date for primary outcome measure) |
Abnormal AFP elevation was usually noted in liver regeneration, HCC, nonseminomatous germ cell tumors or other malignant tumors. However, some studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, we study will recruit the patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed. The hypothesis of this study is that the mutation of AFP gene might be one of the causes of abnormal AFP.
Eligibility| Ages Eligible for Study: | 20 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
The patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups.
Inclusion Criteria:
- The patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. More than 20 years old
Exclusion Criteria:
- Pregnancy
Contacts and Locations| Contact: Jin Chuan Sheu, M.D. Ph.D. | celian0916@yahoo.com.tw |
| Taiwan | |
| National Taiwan University Hospital | Recruiting |
| Taipei, Taiwan, 100 | |
| Contact: Jin-Chuan Sheu, M.D. Ph.D. 886-2-23123456 ext 66579 celian0916@yahoo.com.tw | |
| Principal Investigator: Jin-Chuan Sheu, M.D. Ph.D. | |
| Principal Investigator: | Jin Chuan Sheu, M.D. Ph.D. | National Taiwan University Hospital |
More Information
No publications provided
| Responsible Party: | Jin-Chuan Sheu/ M.D. Ph.D., National Taiwan University Hospital |
| ClinicalTrials.gov Identifier: | NCT01258894 History of Changes |
| Other Study ID Numbers: | 201010019R |
| Study First Received: | November 30, 2010 |
| Last Updated: | December 21, 2010 |
| Health Authority: | Taiwan: Department of Health |
ClinicalTrials.gov processed this record on May 16, 2013