Investigation of Human Alpha-fetoprotein Genes

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT01258894
First received: November 30, 2010
Last updated: December 21, 2010
Last verified: December 2010
  Purpose

Studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, this study will recruit the patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed.


Condition
Elevated or Normal Alpha-fetoprotein Patients

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Investigation of Human Alpha-fetoprotein Genes

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

10c.c Whole Blood


Estimated Enrollment: 300
Study Start Date: December 2010
Estimated Study Completion Date: October 2013
Estimated Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Detailed Description:

Abnormal AFP elevation was usually noted in liver regeneration, HCC, nonseminomatous germ cell tumors or other malignant tumors. However, some studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, we study will recruit the patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed. The hypothesis of this study is that the mutation of AFP gene might be one of the causes of abnormal AFP.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

The patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups.

Criteria

Inclusion Criteria:

  • The patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. More than 20 years old

Exclusion Criteria:

  • Pregnancy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01258894

Contacts
Contact: Jin Chuan Sheu, M.D. Ph.D. celian0916@yahoo.com.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Jin-Chuan Sheu, M.D. Ph.D.    886-2-23123456 ext 66579    celian0916@yahoo.com.tw   
Principal Investigator: Jin-Chuan Sheu, M.D. Ph.D.         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Jin Chuan Sheu, M.D. Ph.D. National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Jin-Chuan Sheu/ M.D. Ph.D., National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01258894     History of Changes
Other Study ID Numbers: 201010019R
Study First Received: November 30, 2010
Last Updated: December 21, 2010
Health Authority: Taiwan: Department of Health

ClinicalTrials.gov processed this record on April 20, 2014