Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this study is to see if glaucoma eye drops (dorzolamide-timolol) have any effect on the duration of an intraocular gas bubble following pars plana vitrectomy.
| Condition | Intervention |
|---|---|
|
Macular Hole Retinal Detachment |
Drug: Dorzolamide 2%-timolol 0.5% topical eyedrops |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Prospective, Randomized Study Comparing the Effects of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy |
- Duration of intraocular gas [ Time Frame: Up to 4 weeks ] [ Designated as safety issue: No ]Patients will self-monitor gas bubble duration and will receive weekly phone calls by the study coordinator until gas disappearance is confirmed.
| Enrollment: | 21 |
| Study Start Date: | February 2010 |
| Study Completion Date: | June 2010 |
| Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: Dorzolamide-timolol topical drops |
Drug: Dorzolamide 2%-timolol 0.5% topical eyedrops
Dorzolamide 2%-timolol 0.5%, 1 drop in operated eye twice daily until gas bubble completely resorbed. Patients randomized to this arm are instructed to use this drop in addition to standard post-operative eye drops.
Other Name: Cosopt
|
| No Intervention: Standard of care |
Detailed Description:
At the end of some retinal surgeries, a gas bubble is placed in the eye. In surgeries for retinal detachment, this gas bubble helps to keep the tear(s) in the retina sealed up while the eye is healing and prevent the retina from re-detaching. In macular hole surgeries (a defect in the center part of the retina), the gas bubble helps to seal up this hole in the center part of the retina. The gas bubble (sulfur hexafluoride) will slowly disappear from the eye over the course of approximately 2 weeks.
In some cases, the gas bubble disappears more quickly than the surgeon would wish. Several eye drops are currently available which help to lower the eye pressure in conditions such as glaucoma where the eye pressure is unacceptably elevated and is causing or may cause vision loss. These drops have been shown to keep the eye pressure controlled after surgery with injection of a gas bubble in the eye. However, little is known about the effect of these drops on the duration of the gas bubble. The goal of this study is to see if these glaucoma eye drops have any effect on the amount of time the gas bubble remains in the eye.
After surgery with a gas bubble (sulfur hexafluoride) is completed, patients will be randomly assigned (like a flip of a coin) to receive a glaucoma drop (dorzolamide-timolol) or no glaucoma drop. These drops are currently available from pharmacies with a prescription and are not "experimental." However, the use of these drops in this protocol is not to treat glaucoma but represents an "off-label" use. Patients assigned to receive a glaucoma drop will be provided with the medication. All patients will receive the standard post-operative drops regardless of which group they are assigned to. Patients will be taken care of before and after the surgery like any other patient undergoing this procedure. The investigators expect that you will be enrolled in this study for 3 months.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients scheduled for pars plana vitrectomy with intraocular gas tamponade with sulfur hexafluoride (e.g., retinal detachment, macular hole, other condition at the discretion of the investigator).
- Ability to provide written informed consent and comply with study assessments for the full duration of the study.
Exclusion Criteria:
- Prior trabeculectomy or tube shunt surgery.
- Current use of topical aqueous suppressants or other glaucoma medications.
- Aphakia or presence of anterior chamber intraocular lens implant.
- Known allergy or contraindication to sulfa or beta-blocker use (e.g., asthma, chronic obstructive pulmonary disease, bradycardia).
Contacts and Locations| United States, Pennsylvania | |
| Wills Eye Institute | |
| Philadelphia, Pennsylvania, United States, 19107 | |
| Principal Investigator: | Jason Hsu, MD | Mid Atlantic Retina |
More Information
Publications:
| Responsible Party: | Michele Formoso, Research Manager, Mid Atlantic Retina |
| ClinicalTrials.gov Identifier: | NCT01257698 History of Changes |
| Other Study ID Numbers: | MAR-2 |
| Study First Received: | December 8, 2010 |
| Last Updated: | February 8, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Mid Atlantic Retina:
|
Vitrectomy Gas bubble Retinal detachment Macular hole Aqueous suppressant |
Additional relevant MeSH terms:
|
Retinal Perforations Retinal Detachment Retinal Diseases Eye Diseases Timolol Dorzolamide Tetrahydrozoline Adrenergic beta-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions |
Physiological Effects of Drugs Anti-Arrhythmia Agents Cardiovascular Agents Therapeutic Uses Antihypertensive Agents Nasal Decongestants Vasoconstrictor Agents Respiratory System Agents Sympathomimetics Autonomic Agents Peripheral Nervous System Agents Carbonic Anhydrase Inhibitors Enzyme Inhibitors |
ClinicalTrials.gov processed this record on May 22, 2013