Selenoprotein P and Non-alcoholic Fatty Liver Disease
The pathogenesis of nonalcoholic fatty liver disease has not been fully elucidated. The most widely supported theory implicates insulin resistance as the key mechanism leading to hepatic steatosis, and perhaps also to steatohepatitis.
Selenoprotein P(SeP) is a secretory protein primarily produced by the liver. Previous studies demonstrated that SeP, a liver-derived secretory protein, causes insulin resistance.
Therefore, the purpose of this study is to determine the different Sep levels between healthy normal group and NAFLD group.
Non-Alcoholic Fatty Liver Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Selenoprotein P and Non-alcoholic Fatty Liver Disease|
- Selenoprotein P [ Designated as safety issue: No ]
- DXA-measured trunk fat mass [ Designated as safety issue: No ]
- CT-measured visceral fat area [ Designated as safety issue: No ]
|Study Start Date:||September 2007|
|Study Completion Date:||August 2008|
|Primary Completion Date:||August 2008 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01257685
|Korea, Republic of|
|Hae Yoon Choi|
|Seoul, Korea, Republic of, 152-703|
|Study Director:||Kyung Mook Choi, MD.PhD||Korea University|