Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health (WEST)
The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.
Device: HEPA filter
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
|Official Title:||Assessing the Impact of Wood Stove Interventions on Air Quality|
- Reactive hyperemia index [ Time Frame: After 1 week of air filtration ] [ Designated as safety issue: No ]
- C-reactive protein [ Time Frame: After 1 week of filtration ] [ Designated as safety issue: No ]
|Study Start Date:||November 2008|
|Study Completion Date:||April 2009|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
Active Comparator: Indoor air HEPA filtration
HEPA filters operating in the participant's bedroom and living room.
Device: HEPA filter
The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.
|Canada, British Columbia|
|Simon Fraser University|
|Burnaby, British Columbia, Canada, V5A 1S6|
|Principal Investigator:||Ryan Allen, PhD||Simon Fraser University|