Impaired Decision-making in Adolescents

This study has been completed.
Sponsor:
Collaborators:
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
UMC Utrecht
ClinicalTrials.gov Identifier:
NCT01253993
First received: March 2, 2007
Last updated: December 3, 2010
Last verified: December 2010
  Purpose

There is clear evidence that aggressive behavior and disruptive behavior disorders (DBD) in middle childhood are associated with an increased risk for substance abuse in adolescence. However, the exact underlying mechanism of this increased risk is unknown. It is likely that a biopsychological vulnerability in some aggressive children and children with DBD makes them liable to substance use and abuse. The investigators hypothesize that deficient decision making is such a biopsychological factor. In this study the investigators aim to test the latter hypothesis by investigating the decision making ability in a group of adolescents with DBD with and without substance use disorders. Decision-making is assessed with the IOWA Gambling Task (GT). This task mimics real-life situations in the way it factors uncertainty, reward and punishment. The GT is specifically designed to assess impaired decision-making in individuals who are unable to learn from their mistakes and make decisions that repeatedly lead to negative consequences. This characteristic may be common to individuals with externalizing disorders such as DBD, psychopathy, and substance use disorders.


Condition Phase
Adolescent Psychiatry
Antisocial Personality Disorders
Substance-Related Disorders
Phase 0

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Impaired Decision-making in Adolescents: A Vulnerability Factor for the Development of Substance Use and Abuse.

Resource links provided by NLM:


Further study details as provided by UMC Utrecht:

Enrollment: 152
Study Start Date: April 2006
Study Completion Date: September 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
Detailed Description:

This study consists of two substudies with adolescents in the age of 14-21 years. The first study group consist of adolescents with DBD with (n=30) and without (n=30) substance use disorders. These adolescents are recruited from orthopsychiatric, forensic psychiatric, and judicial institutions.

The second study group consists of a) ex-patients of the Utrecht Coping Power Program (UCPP)who previously participated to a follow-up study, and b) ex-patients who were treated as a child at an outpatient clinic of the UMC Utrecht. These latter groups were taken together and subdivided into a group with (n=30) and without (n=30) substance use problems.

For both studies healthy controls (n=80) are recruited. The investigators will start with healthy controls from earlier studies, and those are extented and will serve as control group for both studies.

  Eligibility

Ages Eligible for Study:   14 Years to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

DBD adolescents were recruited from judicial and forensic institutions. Healthy controls consisted of volunteers.

Criteria

Inclusion Criteria:

  • Having a DISC diagnosis DBD

Exclusion Criteria:

  • Having the DISC diagnosis Schizophrenia
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01253993

Locations
Netherlands
University Medical Center Utrecht
Utrecht, Netherlands, 3584 CX
Sponsors and Collaborators
UMC Utrecht
ZonMw: The Netherlands Organisation for Health Research and Development
Investigators
Principal Investigator: Walter Matthys, MD, PhD UMC Utrecht
  More Information

Publications:
Responsible Party: W. Matthys, UMC Utrecht
ClinicalTrials.gov Identifier: NCT01253993     History of Changes
Other Study ID Numbers: 05-271, ZonMw 31100001, NIDA DA 16135
Study First Received: March 2, 2007
Last Updated: December 3, 2010
Health Authority: Netherlands: Medical Ethics Review Committee (METC)

Keywords provided by UMC Utrecht:
Disruptive Behavior Disorders, Substance abuse,
Iowa Gambling Task, Decision Making.

Additional relevant MeSH terms:
Antisocial Personality Disorder
Disease
Personality Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Pathologic Processes

ClinicalTrials.gov processed this record on October 23, 2014