Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.
|Official Title:||Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects|
- GLP-1 secretion [ Time Frame: Postprandial ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||October 2010|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
|Type 2 diabetes|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01251510
|Gentofte University Hospital|
|Hellerup, Denmark, 2900|
|Principal Investigator:||David P. Sonne, MD||Gentofte Hospital, University of Copenhagen|