Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?
This study has been withdrawn prior to enrollment.
(Did not begin)
Sponsor:
University of Mississippi Medical Center
Information provided by (Responsible Party):
University of Mississippi Medical Center
ClinicalTrials.gov Identifier:
NCT01248234
First received: November 23, 2010
Last updated: July 12, 2012
Last verified: July 2012
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Purpose
This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.
| Condition | Intervention | Phase |
|---|---|---|
|
Hypertension |
Drug: propofol Drug: Etomidate Drug: Propofol and Etomidate |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Parallel Assignment Masking: Open Label |
| Official Title: | Does Administration of Etomidate and Propofol if the Anesthetic Induction of the Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngosacopy, When Compared to Propofol or Etomidate Alone? |
Resource links provided by NLM:
Further study details as provided by University of Mississippi Medical Center:
Primary Outcome Measures:
- Blood pressure stability during anesthetic induction [ Time Frame: 15 minutes ] [ Designated as safety issue: Yes ]Blood pressure will be measures every minute for 15 minutes following anesthetic induction
| Enrollment: | 0 |
| Study Start Date: | July 2012 |
| Estimated Study Completion Date: | July 2012 |
| Estimated Primary Completion Date: | July 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Propofol
Propofol alone will be used to put an elderly hypertensive patient to sleep for surgery.
|
Drug: propofol
Propofol 1mg/kg will be given once to put the patient to sleep for surgery.
|
|
Active Comparator: Etomidate
Etomidate alone will be used to put an elderly hypertensive patient to sleep.
|
Drug: Etomidate
Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.
|
|
Active Comparator: Propofol and Etomidate
A combination of Etomidate and Propofol will be used to put an elderly hypertensive patient to sleep for surgery.
|
Drug: Propofol and Etomidate
Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.
|
Detailed Description:
Same as above.
Eligibility| Ages Eligible for Study: | 65 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Patients at least 65 years old, with a history of hypertension.
Exclusion Criteria:
- Patients less than 65 years old or without a history of hypertension.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01248234
Locations
| United States, Mississippi | |
| University of Mississippi Medical Center | |
| Jackson, Mississippi, United States, 39216 | |
Sponsors and Collaborators
University of Mississippi Medical Center
Investigators
| Study Chair: | Cynthia A Vaughn, MD | University of Mississippi Medical Center |
More Information
No publications provided
| Responsible Party: | University of Mississippi Medical Center |
| ClinicalTrials.gov Identifier: | NCT01248234 History of Changes |
| Other Study ID Numbers: | 2010-0097 |
| Study First Received: | November 23, 2010 |
| Last Updated: | July 12, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Mississippi Medical Center:
|
elderly hypertensive anesthesia |
Additional relevant MeSH terms:
|
Hypertension Vascular Diseases Cardiovascular Diseases Anesthetics Etomidate Propofol Central Nervous System Depressants |
Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Hypnotics and Sedatives Anesthetics, Intravenous Anesthetics, General |
ClinicalTrials.gov processed this record on May 21, 2013