Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

This study has been withdrawn prior to enrollment.
(Did not begin)
Sponsor:
Information provided by (Responsible Party):
University of Mississippi Medical Center
ClinicalTrials.gov Identifier:
NCT01248234
First received: November 23, 2010
Last updated: July 12, 2012
Last verified: July 2012
  Purpose

This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.


Condition Intervention Phase
Hypertension
Drug: propofol
Drug: Etomidate
Drug: Propofol and Etomidate
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Does Administration of Etomidate and Propofol if the Anesthetic Induction of the Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngosacopy, When Compared to Propofol or Etomidate Alone?

Resource links provided by NLM:


Further study details as provided by University of Mississippi Medical Center:

Primary Outcome Measures:
  • Blood pressure stability during anesthetic induction [ Time Frame: 15 minutes ] [ Designated as safety issue: Yes ]
    Blood pressure will be measures every minute for 15 minutes following anesthetic induction


Enrollment: 0
Study Start Date: July 2012
Estimated Study Completion Date: July 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Propofol
Propofol alone will be used to put an elderly hypertensive patient to sleep for surgery.
Drug: propofol
Propofol 1mg/kg will be given once to put the patient to sleep for surgery.
Active Comparator: Etomidate
Etomidate alone will be used to put an elderly hypertensive patient to sleep.
Drug: Etomidate
Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.
Active Comparator: Propofol and Etomidate
A combination of Etomidate and Propofol will be used to put an elderly hypertensive patient to sleep for surgery.
Drug: Propofol and Etomidate
Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.

Detailed Description:

Same as above.

  Eligibility

Ages Eligible for Study:   65 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients at least 65 years old, with a history of hypertension.

Exclusion Criteria:

  • Patients less than 65 years old or without a history of hypertension.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01248234

Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Sponsors and Collaborators
University of Mississippi Medical Center
Investigators
Study Chair: Cynthia A Vaughn, MD University of Mississippi Medical Center
  More Information

No publications provided

Responsible Party: University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT01248234     History of Changes
Other Study ID Numbers: 2010-0097
Study First Received: November 23, 2010
Last Updated: July 12, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of Mississippi Medical Center:
elderly
hypertensive
anesthesia

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases
Propofol
Etomidate
Anesthetics
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Anesthetics, Intravenous
Anesthetics, General

ClinicalTrials.gov processed this record on September 16, 2014