Cytokine Changes After Colorectal Cancer Resection
Based on our previous research, this study aims to determine reliable surgical stress response markers in patients undergoing radical resection of colorectal cancer.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Postoperative Serum Cytokine Changes After Radical Resection of Colorectal Cancer|
- Postoperative changes of serum cytokine levels [ Time Frame: 1 day, 2 days and 7 days postoperatively ] [ Designated as safety issue: No ]Serum cytokine levels will be determined at 1st, 2nd and 7th postoperative day and compared to preoperative values.
- Early postoperative complications [ Time Frame: Within one month after surgery ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
For each patient, serum samples will be stored at -80°C for later determining of serum cytokine levels
|Study Start Date:||August 2010|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Colorectal cancer patients
Patients with pathohistologically verified colorectal cancer or adenoma with epithelial dysplasia
Procedure: colorectal cancer resection
Open radical resection of colorectal cancer, according to oncological principals, depending on the tumor site
Every surgical intervention represents a stress for patient's organism. During the operation, numerous changes in the patient's metabolism take place, that are termed surgical stress response. Leading cause of surgical stress response is tissue destruction that always accompanies operations. Surgical stress response is effected through activation of hypothalamus-pituitary-adrenal axis and through sympathetic activation.
The consequences of surgical stress response are numerous. Surgical stress response is essential to uneventful postoperative recovery. On the other hand, excessive surgical stress response may lead to serious postoperative complications, such as heart and kidney failure, venous thrombosis, disruption of operative wound and wound infection.
In prior studies the investigators have shown the kinetics of postoperative serum interleukin changes after radical resection of gastric cancer.
This study aims at determining reliable markers of surgical stress response severity in patients undergoing radical resection of colorectal cancer.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01244022
|University Hospital Dubrava|
|Zagreb, Croatia, 10000|
|Principal Investigator:||Drazen Servis, M.D., Ph.D.||University Hospital Dubrava|