Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
| Condition | Intervention | Phase |
|---|---|---|
|
Elective Thyroidectomy |
Drug: Remifentanil |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Prevention |
| Official Title: | Effect of Remifentanil on Cough During Emergence From General Anesthesia : Randomized Trial to Comparison Between Sevoflurane Anesthesia and Propofol Anesthesia |
| Enrollment: | 70 |
| Study Start Date: | September 2010 |
| Study Completion Date: | February 2011 |
| Primary Completion Date: | January 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: propofol |
Drug: Remifentanil
Other Name: Ultiva
|
| Active Comparator: sevoflurane |
Drug: Remifentanil
Other Name: Ultiva
|
Detailed Description:
During recovery from general anesthesia the stimuli of endotracheal tube lead to the coughing, hypertension, tachycardia, which can cause a serious complication.
It has been demonstrated that opioid, intravenous or topical lidocaine administration can attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life, target-controled infusion method to adequately maintain the effect site concentration could help to predict the recovery time to the alert state from the general anesthesia. It is considered proper method of continuous infusion of remifentanil for reducing emergence cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main anesthetic agents, the incidence of coughing when tracheal extubation is reduced after propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
During recovery from general anesthesia the stimuli of endotracheal tube lead to the coughing, hypertension, tachycardia, which can cause a serious complication.
It has been demonstrated that opioid, intravenous or topical lidocaine administration can attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life, target-controled infusion method to adequately maintain the effect site concentration could help to predict the recovery time to the alert state from the general anesthesia. It is considered proper method of continuous infusion of remifentanil for reducing emergence cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main anesthetic agents, the incidence of coughing when tracheal extubation is reduced after propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
Eligibility| Ages Eligible for Study: | 20 Years to 70 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- females
- ASA I-II
- aged between 20 and 70 year
- general anesthesia for elective thyroidectomy
Exclusion Criteria:
- signs of an anatomical or functional abnormality in upper airway
- risk factors for perioperative aspiration
- smoking for recent 8 weeks
- URI or sore throat for recent 2 weeks
- potential of pregnancy
Contacts and Locations| Korea, Republic of | |
| Severance Hospital | |
| Seoul, Korea, Republic of, 120-752 | |
| Principal Investigator: | Jeong-Rim Lee, MD, Ph.D | Severance Hospital, Department of Anesthesiology and Pain Medicine |
More Information
No publications provided
| Responsible Party: | Jeong-Rim Lee / Assistant Professor, Severance Hospital, Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute |
| ClinicalTrials.gov Identifier: | NCT01240109 History of Changes |
| Other Study ID Numbers: | 4-2010-0369 |
| Study First Received: | November 10, 2010 |
| Last Updated: | May 12, 2011 |
| Health Authority: | South Korea: Korea Food and Drug Administration (KFDA) |
Additional relevant MeSH terms:
|
Anesthetics Propofol Sevoflurane Remifentanil Central Nervous System Depressants Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Anesthetics, Intravenous |
Anesthetics, General Hypnotics and Sedatives Platelet Aggregation Inhibitors Hematologic Agents Anesthetics, Inhalation Analgesics, Opioid Analgesics Sensory System Agents Peripheral Nervous System Agents |
ClinicalTrials.gov processed this record on May 19, 2013