Autologous Serum Skin Testing in Patients With Atopic Dermatitis Autologous Serum Skin Testing in Patients With Atopic Dermatitis

This study has been completed.

Sponsor:

Information provided by:

Yuzuncu Yıl University

ClinicalTrials.gov Identifier:

NCT01238263

First received: November 9, 2010

Last updated: NA

Last verified: May 2009

History: No changes posted

Purpose

Recently, IgE-type autoantibodies against self proteins have been detected in the serum of the atopic dermatitis patients. The role of this IgE autoantibodies involved in the pathogenesis of atopic dermatitis is not known, yet. But, there may be a correlation between the severity of the disease and the serum levels of this autoantibodies. The autologous serum skin testing is applied to both atopic dermatitis patients and healthy control and the results are estimated in this study.The investigators detected 70% positive autologous serum skin testing in atopic dermatitis patients and test positivity was higher in patients with atopy history, moderately severe disease calculated by SCORAD index and high serum IgE levels.

Condition
Atopic Dermatitis, Serum Skin Test

Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Prospective

Further study details as provided by Yuzuncu Yıl University:

Enrollment:	90
Study Start Date:	April 2009
Study Completion Date:	August 2010
Primary Completion Date:	June 2010 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	1 Year to 45 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

Criteria

Inclusion Criteria:

Sixty AD patients and 30 healthy individuals

Exclusion Criteria:

. The patients showing evidence of any other disease are not included to our study. No drug was allowed fourteen days prior to the test, including antihistamines and steroids.

Contacts and Locations

No Contacts or Locations Provided

More Information

No publications provided

Responsible Party:	Silvan State Hospital, Dermatology department
ClinicalTrials.gov Identifier:	NCT01238263 History of Changes
Other Study ID Numbers:	yavuzyesilova
Study First Received:	November 9, 2010
Last Updated:	November 9, 2010
Health Authority:	United States: Food and Drug Administration

Keywords provided by Yuzuncu Yıl University:

Atopic dermatitis, autologous serum skin testing, IgE autoantibodies

Additional relevant MeSH terms:

Dermatitis
Dermatitis, Atopic
Skin Diseases
Skin Diseases, Genetic
Genetic Diseases, Inborn

Skin Diseases, Eczematous
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on June 17, 2013

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