Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2010 by Sheffield Teaching Hospitals NHS Foundation Trust.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborator:
University of Sheffield
Information provided by:
Sheffield Teaching Hospitals NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT01235494
First received: November 4, 2010
Last updated: NA
Last verified: November 2010
History: No changes posted
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Purpose
To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas
| Condition | Intervention | Phase |
|---|---|---|
|
Healthy Volunteers |
Other: polarised 3 helium |
Phase 1 |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label |
| Official Title: | Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas |
Further study details as provided by Sheffield Teaching Hospitals NHS Foundation Trust:
| Estimated Enrollment: | 20 |
| Study Start Date: | July 2010 |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: polarised 3 helium
inhaled gas
|
Other: polarised 3 helium
1 inhalation (= 1 litre)
|
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- age 18 -70
Exclusion Criteria:
- contraindication to MRI
- Resting oxygen saturation <95%
- Volunteers requiring bronchodilators less than 4 hourly
- additional respiratory diagnoses
- pregnancy
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01235494
Locations
| United Kingdom | |
| Academic Unit of Radiology, Univeristy of Sheffield | Recruiting |
| Sheffield, South Yorkshire, United Kingdom, S10 2SJ | |
| Contact: Jim Wild, Professor 0114 2265393 l.armstrong@shef.ac.uk | |
| Principal Investigator: Paul Grififths, Professor | |
Sponsors and Collaborators
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield
More Information
No publications provided
| Responsible Party: | Prof Paul Griffiths, Univeristy of Sheffield |
| ClinicalTrials.gov Identifier: | NCT01235494 History of Changes |
| Other Study ID Numbers: | STH15080 |
| Study First Received: | November 4, 2010 |
| Last Updated: | November 4, 2010 |
| Health Authority: | United Kingdom: Medicines and Healthcare Products Regulatory Agency |
ClinicalTrials.gov processed this record on June 18, 2013