Ultrasound in Acute Dyspnea in the Field - Full Text View

Purpose

Acute heart failure is one of the main causes of acute respiratory distres in prehospital emergency setting. The early and correct diagnosis is important because the misdiagnosis can result in deleterious consequeance to patients. Rapid bedside tests (like NT-proBNP) and point-of-care lung ultrasound could be useful methods in field. This study confirmed that the combination of ultrasound sign in combination with rapid NT-proBNP test has a hibh diagnostic accuracy in differentiating between cardiac and pulmonray causes of acute dyspnea in the field and the tretament possibilities in clinical obscure cases are mainly improved.

Condition
Heart Failure COPD Asthma

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Combination of Lung Ultrasound(a Comet-tail Sign) and N-terminal Pro-brain Natriuretic Paptide in Differentiating Acute Dyspnea in Prehospital Emergency Setting

Resource links provided by NLM:

MedlinePlus related topics: Asthma Breathing Problems Heart Failure

U.S. FDA Resources

Further study details as provided by University Clinical Centre, Maribor:

Enrollment:	248
Study Start Date:	July 2007
Study Completion Date:	August 2010
Primary Completion Date:	April 2010 (Final data collection date for primary outcome measure)

Groups/Cohorts
acute dyspnea, field, diagnostic All patients with shortness of breath as the primary complaint (defined as eitherthe sudden onset of dyspnea without history of chronic dyspnea or an increase in the severity of chronic dyspnea and were age >18 years.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

All patients with acute dyspnea in the time o the investigation in the field-prehospital settingInclusion criterion for the study was shortness of breath as the primary complaint (defined as either the sudden onset of dyspnea without history of chronic dyspnea or an increase in the severity of chronic dyspnea). Exclusion criteria were age <18 years, history of renal insufficiency, trauma, severe coronary ischemia (unless patient's predominant presentation was dyspnea), and other causes of dyspnea: pneumonia, pulmonary embolism, carcinoma, pneumothorax, pleural effusion, intoxications (drugs), anaphylactic reactions, upper airway obstruction, bronchial stenosis, and gastroesophageal reflux disorder, according to the history, clinical status, and additional laboratory tests available in prehospital setting (D-dimer, troponin, C-reactive protein)

Criteria

Inclusion Criteria:

Inclusion criterion for the study was shortness of breath as the primary complaint (defined as either the sudden onset of dyspnea without history of chronic dyspnea or an increase in the severity of chronic dyspnea).

Exclusion Criteria:

Exclusion criteria were age <18 years, history of renal insufficiency, trauma, severe coronary ischemia (unless patient's predominant presentation was dyspnea), and other causes of dyspnea: pneumonia, pulmonary embolism, carcinoma, pneumothorax, pleural effusion, intoxications (drugs), anaphylactic reactions, upper airway obstruction, bronchial stenosis, and gastroesophageal reflux disorder

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01235182

Locations

Slovenia
Center for Emergency Medicine maribor
Maribor, Slovenia, 2000

Sponsors and Collaborators

University Clinical Centre, Maribor

Investigators

Principal Investigator:

Štefek Grmec, MD,PhD,Prof.

Center of Health Center for Emergency Medicine Maribor

More Information

Publications:

Klemen P, Golub M, Grmec S. Combination of quantitative capnometry, N-terminal pro-brain natriuretic peptide, and clinical assessment in differentiating acute heart failure from pulmonary disease as cause of acute dyspnea in pre-hospital emergency setting: study of diagnostic accuracy. Croat Med J. 2009 Apr;50(2):133-42.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Prosen G, Klemen P, Štrnad M, Grmec S. Combination of lung ultrasound (a comet-tail sign) and N-terminal pro-brain natriuretic peptide in differentiating acute heart failure from chronic obstructive pulmonary disease and asthma as cause of acute dyspnea in prehospital emergency setting. Crit Care. 2011;15(2):R114. Epub 2011 Apr 14.

Responsible Party:	Prof.Štefek Grmec, MD,PhD, Zdravstveni dom Adolfa Drolca Maribor, Center for Emergency Medicine Maribor
ClinicalTrials.gov Identifier:	NCT01235182 History of Changes
Other Study ID Numbers:	ADMB2010
Study First Received:	November 4, 2010
Last Updated:	November 4, 2010
Health Authority:	Slovenia: National Medical Ettics Committee

Keywords provided by University Clinical Centre, Maribor:

acute dyspnea
prehospital emergency setting
differential diagnosis
ultrasound
NT-proBNP

Additional relevant MeSH terms:

Asthma
Dyspnea
Heart Failure
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity

Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Respiration Disorders
Signs and Symptoms, Respiratory
Signs and Symptoms
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 22, 2013