Emergence Agitation Between Sevoflurane and Desflurane in Pediatric
Sevoflurane is the volatile anesthetic agent of choice in pediatric surgery. Nevertheless, sevoflurane anesthesia had the high incidence of emergence delirium compared to halothane and isoflurane.Bortone L et al.reported isoflurane for maintenance decreased incidence of emergence agitation compared to sevoflurane in unpremedicated preschool children under elective subumbilical surgery (32% versus 52% respectively). Desflurane is the new volatile anesthetic agent which provides faster recovery compared to sevoflurane.Valley et al.reported no significant differences between sevoflurane or desflurane anesthesia in children in term of the serious airway complication such as laryngospasm or desaturation excepted the number of coughing episodes were more frequent in the desflurane compared to sevoflurane (36 versus 18).Mayer J et al. reported sevoflurane had severity of Pediatric Anesthesia Emergence Delirium (PAED) scale higher than desflurane in ear, nose, throat inpatient surgery in children (12(2-20) versus 6(0-15) respectively) with no reported of incidence of emergence agitation between those two. Therefore, the investigators would like to compare the incidence of emergence agitation, recovery profile and respiratory events between desflurane and sevoflurane anesthesia in pediatric ambulatory urologic surgery under general anesthesia and combined with regional anesthesia.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||Comparison the Incidence of Emergence Agitation Between Sevoflurane and Desflurane After Pediatric Urologic Surgery|
- the incidence of emergence agitation [ Time Frame: average recovery room period was 120 minutes ] [ Designated as safety issue: Yes ]to compare the incidence of emergence agitation between sevoflurane anesthesia and desflurane anesthesia in pediatric ambulatory urologic surgery.
- the recovery profile [ Time Frame: average recovery room period was 120 minutes ] [ Designated as safety issue: Yes ]to compare the recovery profile such as awakening time. Duration of PACU stay, and also intraopertive and PACU respiratory adverse events between sevoflurane anesthesia and desflurane anesthesia.
|Study Start Date:||May 2010|
|Study Completion Date:||August 2012|
|Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
Experimental: desflurane anesthesia
maintenance anesthesia with desflurane
Desflurane (not more than 1 MAC) for maintenance of anesthesia in urologic surgery
Other Name: Suprane (desflurane, USP)
Active Comparator: sevoflurane
maintenance anesthesia with sevoflurane
Sevoflurane (not more than 1 MAC) for maintenance of anesthesia in urologic surgery
Other Name: sevorane
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01235143
|Hat yai, Songkhla, Thailand, 90110|
|Principal Investigator:||Maliwan Oofuvong, MD||Prince of Songkla University|