Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock (SEPSICOAG)

Severe septic shock patients entering intensive care units in the participating centers.

Inclusion Criteria:

• patient (or representative) recieved the information notice
• patient has hemodynamic insufficiency of non-traumatic or cardiogenic origin associated with severe sepsis (treated with Noradrenalin) and organ dysfunction, hypoperfusion or hypotension
• body temperature > 38.3°C or < 36°C
• heart rate > 90 bpm
• Tachypnea > 20 C/min or PaCO2 < 32 mmHg or mechanical ventilation
• leucocytes > 12000 µL-1 ou < 4000 µL-1 ou > 10% immature forms
• oliguria < 0.5 ml/kg/h for at least 2 hours
• abrupt alteration (24 h) of conscienceness
• thrombocytopenia < 100 000 G/L or disseminated intravascular coagulation
• mottled skin and / or capillary refill time> 3 sec
• PaO2/FiO2 < 300 mmHg ou < 40KPas
• Lactatemia > 2mMol/l
• septic shock: Systolic Blood Pressure (SBP) > 90 mmHg or need for vasopressors to maintain SBP> 90 mmHg despite a prior filling (20-30 ml / kg of macromolecules or 40 to 60 ml / kg of normal saline (or decrease in SBP> 40% in the hypertensive)

Exclusion Criteria:

• patient is dying or limitation or cessation of active treatment
• patient is already included in another trial
• patient or family refusal
• patient not affiliated with a social security system