The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise (Ad/Ab)

This study has been completed.
Sponsor:
Collaborator:
National Space Biomedical Research Institute
Information provided by (Responsible Party):
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT01228877
First received: October 8, 2010
Last updated: August 14, 2013
Last verified: August 2013
  Purpose

Performing adduction and abduction resistance exercise will increase hip bone density and strength to a greater extent than doing squat and deadlift exercise.

Aim #1: To determine if doing hip adduction and abduction resistance exercise training for 16 weeks improves spine bone mineral density and hip bone mineral density and strength as determined by finite element modeling.

Aim #2: To compare the effects of hip adduction and abduction exercise to squat and deadlift exercise with respect to potential changes in hip bone mineral density and strength.

Aim #3: To determine if the addition of adduction and abduction exercise to squat and deadlift exercise promotes an "additive" effect with respect to changes in spine bone mineral density and hip bone mineral density and bone strength.


Condition Intervention
Performing Adduction and Abduction Resistance Exercise Will Increase Hip Bone Density and Strength to a Greater Extent Than Doing Squat and Deadlift Exercise.
Other: exercise

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise Training on Strength and Density of the Proximal Femur

Resource links provided by NLM:


Further study details as provided by University of California, San Francisco:

Primary Outcome Measures:
  • Reduce risk of hip fracture [ Time Frame: 16 weeks ] [ Designated as safety issue: No ]
    The investigators have prioritized the last year of NSBRI funding to test one the capabilities of our device, standing hip adduction/abduction exercise, to strengthen the proximal femoral bone. We believe that if we are able to detect increases in bone density and strength (assessed using quantitative computed tomography of the hip pre- and post-training) in healthy volunteers, this will be solid preliminary evidence to support modification of exercise protocols currently being used to reduce the rate of bone loss on the International Space Station.


Enrollment: 22
Study Start Date: December 2010
Study Completion Date: September 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise
Adduction, Abduction and Squat exercise three times a week for 16 weeks
Other: exercise
Adduction, Abduction and Squat exercise three times a week for 16 weeks

Detailed Description:

The investigators will carry out a 16-week exercise training study (n=24) consisting of 3 groups (n=8 per group) of healthy, non-resistance trained adult men and women (age 25-55 years). Our aim is to determine if hip adduction and abduction resistance exercise is more effective than squat and deadlift exercise with respect to changes in the whole bone strength and density of the proximal femur and spine.

Group A will do only hip adduction and abduction exercises. Group B will do only squat and deadlift exercise Group C will do a combination of hip adduction and abduction and squat and deadlift exercise

Subjects will be imaged with quantitative computed tomography (QCT) of the proximal femur and spine, pre-training and post-training, to determine changes in spinal bone density and proximal femoral bone density and strength.

Serum assays of bone formation (osteocalcin) and bone resorption (serum CTX type I) will be performed four times during the study at 4 week intervals.

  Eligibility

Ages Eligible for Study:   25 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy men and women
  • Age of 25 to 55 years old

Exclusion Criteria:

  • Hypertension (High blood pressure)
  • Diabetes or metabolic syndrome
  • Hyperlipidemia (High cholesterol)
  • Cardiovascular Disease
  • Asthma or other pulmonary disease (i.e. COPD)
  • not pregnant
  • have no joint or mobility limitations
  • do not exercise on a regular basis
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01228877

Locations
United States, California
UCSF-Department of radiology-China Basin
San Francisco, California, United States, 94107
Sponsors and Collaborators
University of California, San Francisco
National Space Biomedical Research Institute
Investigators
Principal Investigator: Thomas Lang, PhD UCSF-Department of Radiology
  More Information

No publications provided

Responsible Party: University of California, San Francisco
ClinicalTrials.gov Identifier: NCT01228877     History of Changes
Other Study ID Numbers: Ad/Ab exercise
Study First Received: October 8, 2010
Last Updated: August 14, 2013
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on July 31, 2014