A Study Evaluating the Safety, Tolerability and Pharmacokinetics of GDC-0917 Administered to Patients With Refractory Solid Tumors or Lymphoma

Inclusion Criteria:

• Histologically or cytologically documented, locally advanced or metastatic solid tumors or lymphoma for which standard therapy either does not exist or has proven ineffective or intolerable
• Life expectancy >/= 12 weeks
• Adequate hematologic and end organ function
• For female patients of childbearing potential and male patients with partners of childbearing potential, agreement (by patient and/or partner) to use an effective form of contraception and to continue its use for the duration of the study.

Exclusion Criteria:

• Clinically significant history of chronic liver disease, active hepatic infection, evidence of hepatic cirrhosis or Grade >/= 2 liver dysfunction not due to hepatic metastases of cancer, current alcohol abuse, active infections with hepatitis B virus, or hepatitis C virus
• Grade >/= 2 fever or associated constitutional symptoms, or a clinically significant systemic infection within the last month
• Autoimmune disease
• History of clinically significant pulmonary disease
• Need for chronic and continuous systemic or topical corticosteroids or immunosuppressive therapy within 2 weeks prior to study entry or anticipated need of continuous systemic corticosteroids or immunosuppressive therapy during study participation.
• Allergy or hypersensitivity to components of the GDC-0917 formulation
• Palliative radiotherapy within 2 weeks prior to first dose of study drug treatment in Cycle 1
• Experimental therapy within 4 weeks prior to first dose of study drug treatment in Cycle 1
• Major surgical procedure or significant traumatic injury within 4 weeks prior to first dose of study drug treatment in Cycle 1, or anticipation of the need for major surgery during the course of study treatment
• Prior anti-cancer therapy within 4 weeks before the first dose of study drug treatment in Cycle 1
• All acute drug-related toxicities must have resolved prior to study entry, except for alopecia and Grade 1 neuropathy.
• Current severe, uncontrolled systemic disease excluding cancer
• History of clinically significant cardiac dysfunction
• History of malabsorption or other condition that would interfere with enteral absorption
• Any history of active GI bleeding within the past 6 months prior to screening
• Known HIV infection
• Uncontrolled ascites, due to diseases other than cancer, requiring weekly large-volume paracentesis for 3 consecutive weeks prior to enrollment
• Pregnancy, lactation, breastfeeding or unwillingness to use birth control during the study and for 3 months after the last dose of GDC-0917
• Known brain metastases that are untreated, symptomatic, or require therapy to control symptoms