Attenuation of Pain in Men and Women

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2010 by University of Wisconsin, Madison.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT01220414
First received: September 28, 2010
Last updated: October 15, 2010
Last verified: October 2010
  Purpose

The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.


Condition Intervention
Pain
Drug: Naltrexone,
Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Attenuation of Pain in Men and Women: Mechanisms of Exercise-Induced Analgesia

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Pain threshold, pain ratings, and temporal summation [ Time Frame: Before and immediately following the two experimental sessions ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: September 2010
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Men Drug: Naltrexone,
50 mg of naltrexone
Drug: Placebo
sugar pill
Active Comparator: Women Drug: Naltrexone,
50 mg of naltrexone
Drug: Placebo
sugar pill

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: Healthy men and women

-

Exclusion Criteria:

  • current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01220414

Contacts
Contact: Kelli F Koltyn, PhD 608-262-4234 Koltyn@education.wisc.edu

Locations
United States, Wisconsin
University of Wisconsin-Madison Recruiting
Madison, Wisconsin, United States, 52706
Contact: Kelli F Koltyn, Ph.D.    608-262-4234    Koltyn@education.wisc.edu   
Principal Investigator: Kelli F Koltyn, Ph.D.         
Sponsors and Collaborators
University of Wisconsin, Madison
  More Information

No publications provided

Responsible Party: Kelli F. Koltyn, University of Wisconsin
ClinicalTrials.gov Identifier: NCT01220414     History of Changes
Other Study ID Numbers: H-2010-0087
Study First Received: September 28, 2010
Last Updated: October 15, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Naltrexone
Narcotic Antagonists
Physiological Effects of Drugs
Pharmacologic Actions
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 23, 2014