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Resistance Exercise in Healthy Men

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by:
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01220037
First received: October 7, 2010
Last updated: July 19, 2011
Last verified: July 2011
History of Changes
  Purpose

In the present study, the effects of age and dietary intake will be assessed on myocellular characteristics during 72 hours after a resistance type exercise session.


Condition Intervention
Single Bout of Resistance Type Exercise
Standardized Diet
 Behavioral: Adhere to a specific standardized diet for 4 days

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Age and Dietary Protein Intake on Myocellular Characteristics Following a Single Bout of Resistance Exercise in Healthy Men

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle fiber myonuclear and stem cell content [ Time Frame: baseline ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 12 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 24 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 48 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 72 hours after a single bout resistance type exercise ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: April 2010
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Young regular diet
During the time of the study this group will adhere to a standardized regular diet.
 Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young low protein diet
During the time of the study this group will adhere to a standardized low protein diet.
 Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young high protein
During the time of the study this group will adhere to a standardized high protein diet.
 Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Elderly
During the time of the study this group will adhere to a standardized high protein diet
 Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.

  Eligibility

Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men between the ages of 18-30 or 70-85 years

Exclusion Criteria:

  • Subjects with a recent history or current state of cardiovascular disease, COPD, Parkinson, rheumatoid arthritis, musculoskeletal/orthopaedic disorders, renal disorder, cognitive impairment.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01220037

Locations
Netherlands
Maastricht University Medical Centre
Maastricht, Zuid Limburg, Netherlands, 6200MD
Sponsors and Collaborators
Maastricht University Medical Center
  More Information

No publications provided

Responsible Party: Luc JC van Loon, MaastrichtUMC
ClinicalTrials.gov Identifier: NCT01220037     History of Changes
Other Study ID Numbers: MEC 09-3-080
Study First Received: October 7, 2010
Last Updated: July 19, 2011
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

ClinicalTrials.gov processed this record on May 16, 2013