Optimized Radiological Diagnosis of Hepatic Candidiasis During the Treatment of Acute Leukemias

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Zurich
ClinicalTrials.gov Identifier:
NCT01207843
First received: September 21, 2010
Last updated: August 18, 2014
Last verified: August 2014
  Purpose

Hepatic candidiasis is a frequent complication in patients receiving intensive chemotherapy for acute leukemia. Hepatic lesions may be detected by computerized tomographic (CT) scans, but there is no standardized CT protocol for the diagnosis and follow-up of hepatic candidiasis.

The investigators compared the size of the fungal lesions in the chest and abdomen CT. The current analysis aimed to increase the value of CT for the diagnosis and the follow-up of hepatic candidiasis in daily routine.


Condition Intervention Phase
Leukemia
Infection
Behavioral: Imaging
Phase 4

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Verbesserung Der Radiologischen Diagnose Von Hepatolienaler Candidiasis während Der Therapie Der Leukämie

Resource links provided by NLM:


Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • The primary end-point was IFI according to the EORTC/MSG 2008 definitions and bacteraemia [ Time Frame: 2 Years ] [ Designated as safety issue: No ]

Enrollment: 88
Study Start Date: October 2009
Study Completion Date: May 2013
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: Imaging
    CT image validation and lesion measurement, as well as comparison of different CT phases
  Eligibility

Ages Eligible for Study:   16 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

patients with suspected hepatolienal candidiasis.

Criteria

Inclusion criteria:

  • Chest and Abdomen CT with fungal lesion in patients with leukemia

Exclusion criteria:

  • Other liver pathologies
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01207843

Locations
Switzerland
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Thomas Frauenfelder, MD UniversitaetsSpital Zuerich
  More Information

No publications provided

Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT01207843     History of Changes
Other Study ID Numbers: idr-3d-001
Study First Received: September 21, 2010
Last Updated: August 18, 2014
Health Authority: Switzerland: Ethikkommission

Keywords provided by University of Zurich:
Computed tomography

Additional relevant MeSH terms:
Candidiasis
Leukemia
Mycoses
Neoplasms
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on October 20, 2014