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Effect of Ambient Light on the Parameters of the Pupillary Light Reflex

This study has been completed.
Sponsor:
Information provided by:
Rutgers, The State University of New Jersey
ClinicalTrials.gov Identifier:
NCT01207817
First received: January 25, 2010
Last updated: September 22, 2010
Last verified: September 2010
  Purpose

The purpose of this study is to determine the effects of varying luminescent levels on the pupillary response.


Condition Intervention
Healthy Volunteers
Other: Pupillometry

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Ambient Light on the Parameters of the Pupillary Light Reflex

Further study details as provided by Rutgers, The State University of New Jersey:

Primary Outcome Measures:
  • pupillary light reflex: amplitude, latency, maximum constriction velocity, mean constriction velocity and dilation velocity during different levels of ambient light [ Time Frame: Pupillometry readings will be taken at 3 potential light readings low light, intermediate light and high ambient light. A total of 48 readings will be done. All parameters will be done at one sitting and will take approximately 45 minutes to complete. ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: September 2009
Study Completion Date: February 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
no condition
no condition - healthy volunteers
Other: Pupillometry
Pupillometry readings will be taken at low, intermediate and high ambient light

Detailed Description:

Evaluation of the pupillary response is an underemphasized aspect of the assessment of visual function. The pupillary light reflex is one of the few objective indicators of afferent input from the retina and optic nerve. Since the pupillary light reflex is processed through the retina, it may be used to assess visual integrity (1). Pupillometry is a reliable technology capable of providing repetitive data on quantitative pupillary function in states of health and disease (2). Amplitude, latency, maximum constriction velocity, mean constriction velocity, and dilation velocity are measured using the Neuroleptics pupillometer. The effects of varying levels of ambient light on these parameters of the pupillary response have not been extensively studied. The purpose of this investigation is to determine the effects of varying luminescent levels on the pupillary response.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy volinteers

Criteria

Inclusion Criteria:

  • healthy volunteers

Exclusion Criteria:

  • recent bout of conjunctivitis or infection in the eye recent eye surgery seizure disorder unable to lie flat for 30 minutes known history of eye disease which cannot be corrected with lenses
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01207817

Locations
United States, New Jersey
UMDNJ-University Hospital
Newark, New Jersey, United States, 07101
Sponsors and Collaborators
University of Medicine and Dentistry of New Jersey
Investigators
Principal Investigator: Lawrence W Chinn, MD UMDNJ-NJMS
  More Information

No publications provided

Responsible Party: Lawrence Chin, MD, UMDNJ
ClinicalTrials.gov Identifier: NCT01207817     History of Changes
Other Study ID Numbers: 0120090181
Study First Received: January 25, 2010
Last Updated: September 22, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by Rutgers, The State University of New Jersey:
a light flash in each eye for a total of 48 measurements

ClinicalTrials.gov processed this record on November 25, 2014