Effect of Ambient Light on the Parameters of the Pupillary Light Reflex
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Purpose
The purpose of this study is to determine the effects of varying luminescent levels on the pupillary response.
| Condition | Intervention |
|---|---|
|
Healthy Volunteers |
Other: Pupillometry |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Effect of Ambient Light on the Parameters of the Pupillary Light Reflex |
- pupillary light reflex: amplitude, latency, maximum constriction velocity, mean constriction velocity and dilation velocity during different levels of ambient light [ Time Frame: Pupillometry readings will be taken at 3 potential light readings low light, intermediate light and high ambient light. A total of 48 readings will be done. All parameters will be done at one sitting and will take approximately 45 minutes to complete. ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 30 |
| Study Start Date: | September 2009 |
| Study Completion Date: | February 2010 |
| Primary Completion Date: | February 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
no condition
no condition - healthy volunteers
|
Other: Pupillometry
Pupillometry readings will be taken at low, intermediate and high ambient light
|
Detailed Description:
Evaluation of the pupillary response is an underemphasized aspect of the assessment of visual function. The pupillary light reflex is one of the few objective indicators of afferent input from the retina and optic nerve. Since the pupillary light reflex is processed through the retina, it may be used to assess visual integrity (1). Pupillometry is a reliable technology capable of providing repetitive data on quantitative pupillary function in states of health and disease (2). Amplitude, latency, maximum constriction velocity, mean constriction velocity, and dilation velocity are measured using the Neuroleptics pupillometer. The effects of varying levels of ambient light on these parameters of the pupillary response have not been extensively studied. The purpose of this investigation is to determine the effects of varying luminescent levels on the pupillary response.
Eligibility| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Healthy volinteers
Inclusion Criteria:
- healthy volunteers
Exclusion Criteria:
- recent bout of conjunctivitis or infection in the eye recent eye surgery seizure disorder unable to lie flat for 30 minutes known history of eye disease which cannot be corrected with lenses
Contacts and Locations| United States, New Jersey | |
| UMDNJ-University Hospital | |
| Newark, New Jersey, United States, 07101 | |
| Principal Investigator: | Lawrence W Chinn, MD | UMDNJ-NJMS |
More Information
No publications provided
| Responsible Party: | Lawrence Chin, MD, UMDNJ |
| ClinicalTrials.gov Identifier: | NCT01207817 History of Changes |
| Other Study ID Numbers: | 0120090181 |
| Study First Received: | January 25, 2010 |
| Last Updated: | September 22, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Medicine and Dentistry New Jersey:
|
a light flash in each eye for a total of 48 measurements |
ClinicalTrials.gov processed this record on May 22, 2013