Confocal Laser Micro-endoscopy in Chronic Obstructive Pulmonary Disease (COPD) and Lung Transplant Recipients
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described small airway remodelling in these patients.
Chronic Obstructive Pulmonary Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients|
|Study Start Date:||September 2010|
COPD Gold class 1-4
Lung transplant recipients
Patients with normal spirometric data
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay and matrix remodelling could be responsible for these changes. Using CLME changes of in the bronchiolar wall and alveolar ducts can be visualized, described and measured.
In lung transplant recipients, CMLE will be performed to distinguish characteristics of distal airways in stabile patient in contrast to patients with bronchiolitis obliterans syndrome.
In both groups data will be correlated with CT findings, pulmonary function tests and anatomopathological results.
|Contact: Jonas Yserbyt, MDfirstname.lastname@example.org|
|Contact: Christophe Dooms, PhDemail@example.com|
|University Hospitals Leuven||Recruiting|
|Leuven, Belgium, 3000|
|Contact: jonas Yserbyt, MD +3216340442 firstname.lastname@example.org|
|Principal Investigator:||Jonas Yserbyt, MD||University Hospitals Leuven|
|Principal Investigator:||Chistophe Dooms, MD, PhD||University Hospitals Leuven|
|Study Chair:||Marc Decramer, MD, PhD||University Hospitals Leuven|
|Study Chair:||Geert Verleden, Md, PhD||University Hospitals Leuven|
|Study Chair:||Wim Janssens, MD, PhD||University Hospitals Leuven|