Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder (MBT)
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Purpose
Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.
| Condition | Intervention |
|---|---|
|
Depression Personality Disorder |
Other: MBT Other: treatment as usual |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Investigator) Primary Purpose: Treatment |
| Official Title: | Mentalization - Based Treatment for Young People Presenting With Co-morbid Depression and Symptoms of Emerging Personality Disorder: Prospective Controlled Trial. |
- Global assessment of functioning [ Time Frame: 2 years post discharge ] [ Designated as safety issue: No ]Measures global functioning
- Global assessment of functioning [ Time Frame: within 1 week of admission ] [ Designated as safety issue: No ]measures level of functioning
- global assessment of functioning [ Time Frame: Average of 8 weeks ] [ Designated as safety issue: No ]measures level of functioning
- mood and feelings questionnaire [ Time Frame: 2 years post discharge ] [ Designated as safety issue: No ]Assesses mood in terms of number of depressive symptoms
- Mood and feelings questionnaire [ Time Frame: Within 1 week of admission ] [ Designated as safety issue: No ]Assesses mood in terms of number of depressive symptoms
- mood and feelings questionnaire [ Time Frame: At average of 8 weeks ] [ Designated as safety issue: No ]Assesses mood in terms of number of depressive symptoms
| Estimated Enrollment: | 75 |
| Study Start Date: | December 2010 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: MBT group
mentalization based treatment program
|
Other: MBT
The intervention consists of twice weekly individual MBT therapy, group therapy with an MBT focus and weekly MBFT, which is MBT for families. The treatment duration will be 6-8 weeks.
Other Name: Psychotherapeutic program
|
|
Active Comparator: Treatment as usual group
treatment as usual group
|
Other: treatment as usual
less intensive and structured psychotherapeutic program
Other Name: Psychotherapeutic program
|
Detailed Description:
Systematic literature review on outcomes with young people with depression and emerging personality disorder showed clear evidence that this group of young people are severely hampered and adult outcomes are strongly linked to both adult PD as well as adult psychiatric disturbance and lower levels of adult functioning. (Crawford et al, 2008; Kasen et al, 1999; Kasen et al, 2007; Lewinsohn et al, 1999) This argues very clearly for the need to diagnose young people presenting with co-morbid depression and emerging personality disorder in order to intervene and help these young people's struggles as it will prevent poor prognostic adult outcomes. There were no treatment programs that specifically focussed on the treatment of this co-morbid group in the literature. Several studies focussed on the treatment of depression alone and only one RCT focussed on the treatment of adolescent personality disorder (Chanen et al, 2007). In adult studies mentalization-based treatment programs were found to be effective ( as well as cost effective) in a day hospital setting for adults with personality disorder and depression (Bateman, et al, 2007) This study aims to conduct a control trial to test whether MBT will be more effective than TAU in this group. All cases will be tested on admission, at discharge and followed up at 2 years post discharge.
Eligibility| Ages Eligible for Study: | 12 Years to 17 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- all young people who are admitted to Brookside adolescent unit between the ages 12 - 17 presenting with depression and emerging personality disorder will be eligible
Exclusion Criteria:
- Young people with autistic spectrum disorders or severe learning disabilities.
Contacts and Locations| Contact: trudie I Rossouw, Dr | +448446001200 | trudie.rossouw@nelft.nhs.uk |
| United Kingdom | |
| North East London Foundation Trust | Recruiting |
| Ilford, Essex, United Kingdom, IG3 8XQ | |
| Contact: trudie i rossouw, dr +448446001200 | |
| Principal Investigator: trudie i rossouw, dr | |
| Principal Investigator: | trudie i rossouw, dr | North East London Foundation Trust |
More Information
Additional Information:
Publications:
| Responsible Party: | Dr T Rossouw, North East London Foundation Trust |
| ClinicalTrials.gov Identifier: | NCT01204346 History of Changes |
| Other Study ID Numbers: | TRossouw |
| Study First Received: | September 16, 2010 |
| Last Updated: | July 21, 2011 |
| Health Authority: | United Kingdom: National Health Service |
Keywords provided by North East London Foundation Trust:
|
adolescents MBT depression emerging personality disorder |
Additional relevant MeSH terms:
|
Personality Disorders Depression Depressive Disorder Mental Disorders Behavioral Symptoms |
Mood Disorders Psychotropic Drugs Central Nervous System Agents Therapeutic Uses Pharmacologic Actions |
ClinicalTrials.gov processed this record on May 23, 2013