fMRI Cholinergic Mechanisms in Schizophrenia
This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||fMRI Cholinergic Mechanisms in Schizophrenia|
- Neuronal response during sensory gating [ Time Frame: Immediate ] [ Designated as safety issue: No ]
|Study Start Date:||October 2008|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Patients with schizophrenia treated with clozapine
This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.
|United States, Colorado|
|VA Eastern Colorado Health Care System, Denver|
|Denver, Colorado, United States, 80220|
|Principal Investigator:||Jason R. Tregellas, PhD||VA Eastern Colorado Health Care System, Denver|