Pazopanib and Everolimus in Patients With Advanced Solid Tumors and Previously Treated Kidney Cancer

This study has suspended participant recruitment.
(Enrollment will resume once new arm (bladder) is approved and activated.)
Sponsor:
Collaborators:
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
GlaxoSmithKline
Novartis
Information provided by (Responsible Party):
Toni Choueiri, MD, Dana-Farber Cancer Institute
ClinicalTrials.gov Identifier:
NCT01184326
First received: August 17, 2010
Last updated: January 14, 2014
Last verified: January 2014
  Purpose

This research study is evaluating the combination of pazopanib and everolimus in patients that have a malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective, or metastatic or locally advanced unresectable kidney cancer. In this research study the investigators are testing the safety of the combination of pazopanib and everolimus as well as to find the appropriate dose to use for further studies.


Condition Intervention Phase
Solid Tumor
Kidney Cancer
Drug: pazopanib
Drug: everolimus
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase I Study of Pazopanib and Everolimus in Patients With Advanced Solid Tumors and Previously Treated Kidney Cancer

Resource links provided by NLM:


Further study details as provided by Dana-Farber Cancer Institute:

Primary Outcome Measures:
  • Maximum tolerated dose [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
    To determine the maximum tolerated dose and dose limiting toxicities of the combination of pazopanib and everolimus

  • Expansion Cohort: Safety [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
    To determine the safety of pazopanib and everolimus in patients with metastatic kidney cancer who have had previous treatment with VEGF receptor inhibition.


Secondary Outcome Measures:
  • Pharmacokinetics [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    To determine the pharmacokinetics of the combination of pazopanib and everolimus.

  • Expansion Cohort: Response [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    To determine the objective resonse proportion, progression-free survival, and duration of response.


Estimated Enrollment: 44
Study Start Date: September 2010
Estimated Study Completion Date: June 2015
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: pazopanib
    Taken orally once daily
    Drug: everolimus
    Taken orally once daily
    Other Name: RAD001
Detailed Description:
  • This protocol has two parts, Phase I and Expansion Cohort. Once the maximum tolerated dose has been identified in the Phase I portion, an expansion cohort of patients with metastatic or locally advanced unresectable kidney cancer will be enrolled.
  • Each treatment cycle lasts 4 weeks during which the participant will be taking pazopanib and everolimus orally daily.
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Phase I: Participants must have histologically confirmed malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effected.
  • Expansion Cohort Only: Participants must have histologically or cytologically confirmed metastatic or locally advanced unresectable kidney cancer.
  • Expansion Cohort Only: Participants must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension at 20mm or greater with conventional techniques or as 10mm or greater with spiral CT.
  • Expansion Cohort Only: Previously treated with at least one anti-angiogenic agent, including but not limited to bevacizumab, sunitinib, or sorafenib. No more than 4 lines of prior systemic therapy for kidney cancer, mTOR pathway inhibitors other than RAD001 are allowed.
  • 18 years of age or older
  • Life expectancy of greater than 3 months
  • ECOG performance status of 0 or 1
  • Normal organ and marrow function as outlined in the protocol
  • Able to swallow oral medications
  • Resolution of any pre-existing toxicity from prior therapy to NCI CTCAE v4.0 grade 1 or less
  • Women are eligible to participate if she is of non-child bearing potential or agrees to use adequate contraception
  • Female subjects who are lactating should discontinue nursing prior to the first dose of study drug and should refrain from nursing throughout the treatment period and for 14 days following the last dose of study drug
  • A male with a female partner of childbearing potential must use a barrier method of contraception or abstinence during the study

Exclusion Criteria:

  • Participants who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study or thos who have not recovered from adverse events due to agents administered more than 4 weeks earlier. Current treatment with leuprolide or other GnRH agonists is permitted on the Phase 1 portion of the study.
  • Participants may not be receiving any other study agents.
  • Prior RAD001 or pazopanib therapy
  • History of clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, except for individuals who have previously treated CNS metastases, are asymptomatic, and have had no requirement for steroids or anti-seizure medication for 6 weeks prior to the first dose of study drug.
  • Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib or everolimus
  • History of any of the following cardiovascular conditions within the past 6 months: Cardiac angioplasty or stenting; myocardial infarction; unstable angina; coronary artery by-pass graft surgery; symptomatic peripheral vascular disease; Class III or IV congestive heart failure
  • Poorly controlled hypertension
  • History of cerebrovascular accident, pulmonary embolism, or untreated deep venous thrombosis within the past 6 months
  • Prior major surgery or trauma within 28 days prior to first dose of study drug, and/or not recovered from effects of that surgery, and/or presences of an non-healing wound, fracture or ulcer, or patients that may require surgery during the course of treatment
  • Evidence of active bleeding or bleeding diathesis
  • Known endobronchial lesions or involvement of large pulmonary vessels by tumor
  • Hemoptysis within 6 weeks of the first dose of study drug
  • Clinically significant gastrointestinal abnormalities that may increase the risk of GI bleeding
  • Expansion Cohort Only: Currently active second malignancy other than non-melanoma skin cancers
  • Presence of uncontrolled infection
  • Liver disease such as chronic cirrhosis, active hepatitis or chronic persistent hepatitis
  • Uncontrolled diabetes
  • Pregnant or breastfeeding
  • Chronic treatment with systemic corticosteroids or other immunosuppressive agent
  • Treatment with strong CYP3A4 inhibitors
  • Treatment with strong CYP3A4 inducers
  • Patients should not receive immunization with attenuated live vaccines within one week of study entry or during study period
  • Prolongation of corrected QT interval > 480msecs
  • History of malabsorption syndrome, disease significantly affecting gastrointestinal function or major resection of stomach or small bowel that could interfere with absorption, distribution, metabolism, or excretion of study drugs
  • Any ongoing toxicity from prior anti-cancer therapy that is greater than grade 1 and/or that is progressing in severity.
  • Any serious and/or pre-existing medical, psychiatric, or other condition that could interfere with subject safety, obtaining informed consent or compliance with study procedures
  • HIV-positive individuals on combination antiretroviral therapy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01184326

Locations
United States, Massachusetts
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
GlaxoSmithKline
Novartis
Investigators
Principal Investigator: Jonathan Rosenberg, MD Dana-Farber Cancer Institute
  More Information

No publications provided

Responsible Party: Toni Choueiri, MD, Assistant Professor of Medicine, Dana-Farber Cancer Institute
ClinicalTrials.gov Identifier: NCT01184326     History of Changes
Other Study ID Numbers: 10-166
Study First Received: August 17, 2010
Last Updated: January 14, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Dana-Farber Cancer Institute:
RAD001
pazopanib
everolimus
advanced cancer

Additional relevant MeSH terms:
Carcinoma, Renal Cell
Kidney Neoplasms
Neoplasms
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Everolimus
Sirolimus
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Anti-Bacterial Agents
Anti-Infective Agents
Therapeutic Uses
Antibiotics, Antineoplastic
Antineoplastic Agents
Antifungal Agents

ClinicalTrials.gov processed this record on August 27, 2014