Corneal Biomechanics With Hydration in Normal and LASIK Eyes
The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Analysis of Corneal Biomechanics Based Upon Central and Peripheral Corneal Thickness in Normal and Post Refractive Surgery Eyes|
- Corneal hydration (swelling) [ Time Frame: Two hours ] [ Designated as safety issue: No ]
|Study Start Date:||February 2004|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Active Comparator: non-LASIK
These participants have NOT had LASIK surgery.
Other: No Intervention
Participant has healthy eyes not altered by LASIK surgery.
Active Comparator: LASIK
These participants have had LASIK surgery.
Procedure: LASIK surgery
Participants have received LASIK surgery and their eyes are healthy.
Other Name: Refractive Surgery
The research will utilize LASIK and non-LASIK populations to analyze the biomechanical differences between these corneas. Subjects' corneas will be swelled with warmed, humidified nitrogen using modified diving goggles to assess structural changes due to a two hour swelling period. Subjects will be examined prior to swelling by a registered ophthalmologist to ensure that the cornea is healthy enough to undergo the swelling procedure. Pre-swelling and post-swelling data will be compared for parameters such as elasticity, density, thickness, axial and tangential curvature, hydration, and intraocular pressure in the central, paracentral, and peripheral regions. Analysis of pre-swelling and post-swelling data will allow for a better understanding of the structural changes created by LASIK. In addition, this project will allow for a better understanding of how common fluctuations in hydration levels affect normal corneal parameters as given by common devices in both populations to allow for corrections for more accurate measurements.
|United States, Ohio|
|Ophthalmology Department (Gowdy Field Building, 5th Floor)|
|Columbus, Ohio, United States, 43212|
|Principal Investigator:||Deborah M Grzybowski, PhD||Ohio State University|