Transformation of Somatosensory and Visual Coordinate Systems

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2013 by Chang Gung Memorial Hospital
Sponsor:
Information provided by (Responsible Party):
Yu-Cheng Pei, Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier:
NCT01177462
First received: July 29, 2010
Last updated: September 23, 2013
Last verified: September 2013
  Purpose

Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.


Condition
Stroke

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Transformation of Coordinates Between Somatosensory and Visual Systems: a Neurophysiological Study

Further study details as provided by Chang Gung Memorial Hospital:

Primary Outcome Measures:
  • Perceived direction of tactile motion [ Time Frame: Once; specifically for stroke patients, 6 months after the onset of stroke ] [ Designated as safety issue: No ]

    Detail description for time frame of assessment:

    (1) for stroke patients, the assessment will be performed "in average" 6 months after the onset of stroke (2) for normal subjects: assessment will be done when the subject is willing to participate (3) the subject might come to the lab more than once if the experiment can not be completed in one session

    Assessment:

    We present tactile motion using tactile stimulators to (1)different digits (2)different hand conformations and (3) different hand positions relative to the trunk



Estimated Enrollment: 90
Study Start Date: March 2011
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
hemineglect stroke patients
Stroke patients with hemineglect
Control stroke patients
Stroke patients without hemineglect
Normal control
Normal subjects

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We will recruit 40 normal healthy adult subjects (equal to and more than 18 years old); the exclusion criteria are subjects with brain pathology, peripheral neuropathy and limb amputation. We will also recruit 50 stroke patients, the including criteria are stroke patients with stable medical condition and being capable of receiving the evaluations. In this group, stroke patients with peripheral neuropathy, and unstable medical condition.

Criteria

For stoke patients

Inclusion Criteria:

  • stroke patients
  • stable medical condition
  • can cooperate in evaluation

Exclusion Criteria:

  • peripheral neuropathy
  • limb ambulation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01177462

Locations
Taiwan
Chang Gung Memorial Hospital Recruiting
Taoyuan County, Taiwan, 333
Contact: Yu-Cheng Pei, MD PhD    +886-3-3281200 ext 3846    yspeii@adm.cgmh.org.tw   
Sponsors and Collaborators
Chang Gung Memorial Hospital
Investigators
Principal Investigator: Yu-Cheng Pei, MD PhD Chang Gung Memorial Hospital
  More Information

No publications provided

Responsible Party: Yu-Cheng Pei, Attending Physician, Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier: NCT01177462     History of Changes
Other Study ID Numbers: CMRPG590021G
Study First Received: July 29, 2010
Last Updated: September 23, 2013
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Chang Gung Memorial Hospital:
coordinate system
normal

ClinicalTrials.gov processed this record on October 21, 2014