The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia
Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Prevention
- Creatinine Clearance [ Time Frame: 2hr after the start of hypotensive anesthesia ] [ Designated as safety issue: No ]
Hypotensive anesthesia means that we maintain the mean blood pressure between 55 & 65 mmHg during surgery to decrease the blood loss.
The specific time point is exactly 2hr after we star to lower the blood pressure.
|Study Start Date:||August 2010|
|Study Completion Date:||December 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
|Experimental: nicardipine||Drug: Nicardipine|
|Active Comparator: remifentanil||
0.1-0.5 ugkg/min during hypotensive anesthesia
Other Name: ultiva®
Please refer to this study by its ClinicalTrials.gov identifier: NCT01175746
|Principal Investigator:||Ji Young Kim||Severance hospital, YUHS|