Creatine Augmentation in Veterans With SSRI-Resistant Major Depression

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Doug Kondo, University of Utah
ClinicalTrials.gov Identifier:
NCT01175616
First received: August 3, 2010
Last updated: May 20, 2014
Last verified: May 2014
  Purpose

The purpose of this study is to determine whether creatine will be helpful as an adjunctive treatment for treatment-resistant major depressive disorder (MDD) in female and male Veterans. We hypothesize that Veterans receiving creatine will show decreased depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS). We will also use 31-Phosphorus Magnetic Resonance Spectroscopy (31-P MRS) brain scans to compare levels of neurochemicals related to energy metabolism in the brain, before-and-after treatment with creatine, and between healthy controls and MDD participants.


Condition Intervention Phase
Major Depressive Disorder
Drug: Creatine
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Creatine Augmentation in Female & Male Veterans With Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder

Resource links provided by NLM:


Further study details as provided by University of Utah:

Primary Outcome Measures:
  • Change in Montgomery-Asberg Depression Rating Scale (MADRS) Score [ Time Frame: screening; baseline; weeks 1, 2, 4, 5, 8, and 10 ] [ Designated as safety issue: No ]
    The primary clinical outcome measure will be the change in MADRS; response will be defined as a 50% or greater decrease in MADRS score from baseline and a Clinical Global Impression Scale (CGI) improvement score of 1 or 2


Secondary Outcome Measures:
  • Changes in 3T 31Phosphorus Magnetic Resonance Spectroscopy metabolites [ Time Frame: Baseline and 8 weeks ] [ Designated as safety issue: No ]
    The primary neuroimaging outcome measures will be changes in 3T 31P-MRS metabolites (PCr and β-NTP) globally and in the anterior cingulate cortex


Estimated Enrollment: 40
Study Start Date: September 2012
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Healthy Control
20 adult male veterans free from psychiatric disorders or uncontrolled medical illnesses will be recruited as healthy controls. They will not receive creatine treatment.
Experimental: Creatine
20 adult male veterans with SSRI-resistant major depression will be treated with Creatine 5 grams per day for eight weeks.
Drug: Creatine
Creatine will be given at a dose of 5 grams per day to adult male veterans with SSRI-resistant depression for eight weeks. Creatine is dispensed as a powder.
Other Name: Creapure

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria for Major Depressive Disorder Participants:

  • Must meet DSM-IV TR criteria for MDD, with current depressive episode lasting 4 weeks or greater.
  • Age 18-55 years
  • Male
  • Montgomery-Asberg Depression Rating Scale (MADRS) of 18 or greater
  • Adequate trial of current SSRI antidepressant treatment, with no change in dose for 4 weeks for greater prior to baseline MRI/MRS scan
  • Minimal or no response to current antidepressant medication

Exclusion Criteria for Major Depressive Disorder Participants:

  • Unstable co-morbid medical, neurologic, or psychiatric illness
  • Clinically significant substance use disorder
  • Significant risk of suicide, as defined by score of 4 or greater on item 10 of the MADRS or in the clinical judgment of the study physician
  • Inability to give informed consent
  • Contraindication to MRI (e.g., pacemaker, ferromagnetic implants in the body, claustrophobia)
  • Individuals with known pre-existing renal disease or who are found to have proteinuria or microalbuminuria at baseline screening
  • History of hypersensitivity to creatine

Inclusion Criteria for Control Participants:

  • Physically and mentally healthy
  • Age 18-55 years
  • Male

Exclusion Criteria for Control Subjects:

  • Any history of psychiatric illness or clinically significant substance use disorder
  • Any significant medical or neurological condition which is likely to impact the central nervous system and/or affect the results of MRS imaging
  • Inability to give informed consent
  • Any medications which are likely to affect the results of MRS imaging as determined by the PI
  • Contraindication to MRI (e.g., pacemaker, ferromagnetic implants in the body, claustrophobia)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01175616

Sponsors and Collaborators
University of Utah
Investigators
Study Director: Perry Renshaw, MD, PhD, MBA University of Utah
  More Information

Additional Information:
Publications:
Responsible Party: Doug Kondo, MD, University of Utah
ClinicalTrials.gov Identifier: NCT01175616     History of Changes
Other Study ID Numbers: 00041936
Study First Received: August 3, 2010
Last Updated: May 20, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by University of Utah:
Depression
Males
Adults

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders
Serotonin Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Serotonin Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on July 31, 2014