Aspirin Responsiveness and Outcome in Coronary Artery Bypass Graft (CABG) Surgery
In patients undergoing coronary artery bypass graft (CAGB) surgery, aspirin is commonly prescribed to prevent graft thrombosis and myocardial ischemia. However, there are still a significant number of grafts occluding in the postoperative period. This is partly attributed to reduced aspirin responsiveness, also called "aspirin resistance". At the moment, no standardized definition or laboratory test is available to quantify "aspirin resistance", and strong platelet reactivity in laboratory tests is not necessarily associated with increased thrombotic events. However, there is increasing evidence that reduced aspirin responsiveness in platelet function analyzers is associated with adverse long-term outcome and higher incidence of major adverse events in patients with stable coronary artery disease and in patients undergoing percutaneous coronary intervention. In patients undergoing coronary artery bypass graft surgery, the predictive value of a laboratory finding of reduced aspirin responsiveness remains unclear.
Therefore, the aim of this study is to prospectively evaluate whether the pre- and/or postoperative laboratory finding of reduced aspirin responsiveness defined by MultiplateTM platelet function analyzer is associated with higher incidences of adverse outcome after 30 days and 12 months in patients undergoing CABG surgery.
Coronary Artery Bypass Graft Triple Vessel
Antithrombotic Drugs [Platelet-aggregation Inhibitors] Causing Adverse Effects in Therapeutic Use
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Comparative Cohort Study on the Outcome of Patients With Normal and Reduced Acetylsalicylic Acid Responsiveness Undergoing Coronary Artery Bypass Surgery|
|Study Start Date:||June 2010|
|Estimated Study Completion Date:||June 2013|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Normal aspirin responsiveness in ASPI test (Multiplate)
Reduced aspirin responsiveness in ASPI test (Multiplate)
|Department of Anaesthesia and Intensive Care Unit, Univeristy Hospital Basel, Switzerland|
|Basel, Basel-Stadt, Switzerland, 4031|
|Principal Investigator:||Daniel Bolliger, MD||Department of Anaesthesia and Intensive Care Unit, University Hospital Basel, Switzerland|