TMS Stimulation and Cognitive Training in Alzheimer Patients

Inclusion Criteria:

• Male or female age 55-85 years
• Patients diagnosed with early or moderate stage of Alzheimer's disease, according to the DSM-IV criteria.
• MMSE score 18 to 24
• Global Dementia rating 1 or 2
• Physically acceptable for the study as confirmed by medical history and exam, clinical laboratory results and EKG
• Spouse, family member or professional caregiver agree and capable of taking care and responsibility for the participation of the patient in the study (answering questions regarding the patient's condition and assuming responsibility for medication)
• Written informed consent by both patient and legally responsible caregiver.
• Able to undergo MRI scan and EEG recordings prior to the onset of the study.
• Agreement to participate in up to 9 months the study.
• Right handed
• Hebrew or Russian as mother tongue and/or ability to read and understand the inform consent form (ICF), and the Patient Information document in Hebrew or Russian.

Exclusion Criteria:

• Severe agitation;
• Mental retardation;
• Unstable medical condition;
• Use of benzodiazepines or other hypnotics during the study and preceding two weeks;
• Pharmacological immunosuppression;
• Participation in a clinical trial with any investigational agent within two weeks prior to study enrollment;
• Alcoholism;
• History of Epileptic Seizures or Epilepsy;
• Contraindication for performing MRI scanning;
• Contraindication for receiving TMS treatment according to a TMS questionnaire;
• Clinically significant abnormal laboratory findings which have not been approved by the Principle Investigator;
• Patients treated with cholinesterase inhibitors, or memantine or ginko-biloba will be allowed to participate, if the treatment has started at least 2 months previous to recruited.