Pilot Study of Oligonol Supplementation to Promote Cardiovascular Health
The investigators hypothesize that acute consumption of Oligonol, a patented lychee fruit extract (Amino Up Chemical Co.) particularly rich in low molecular weight flavanols, will improve endothelial function, reduce platelet reactivity and increase circulating levels of flavonoids after a single intake.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||Effects of Oligonol on Vascular Function and Inflammation in Healthy Men: A Double-Blind, Dose-Finding Study|
- Peripheral Arterial Tonometry [ Time Frame: 0 and 2 hours ] [ Designated as safety issue: No ]
|Study Start Date:||August 2008|
|Study Completion Date:||February 2009|
|Primary Completion Date:||February 2009 (Final data collection date for primary outcome measure)|
|Experimental: 100 mg of Oligonol||Dietary Supplement: Oligonol|
|Experimental: 200 mg of Oligonol||Dietary Supplement: Oligonol|
|Placebo Comparator: 0 mg of Oligonol||Dietary Supplement: Oligonol|
The investigators have demonstrated from previous studies at UC Davis that a single dose of a high-flavanol supplement from cocoa can improve endothelial function, measured by increased blood flow from peripheral arterial tonometry (PAT), reduce platelet reactivity, and increase circulating levels of flavonoids in the blood. The investigators seek with this proposal to determine if a similar response can be noted with a different high-flavanol supplement in normal, healthy people.