Genetic Contributions to Autism Spectrum Disorders
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Purpose
This study is working towards gaining a better understanding of the genetic and environmental factors involved in autism spectrum disorders (ASD), which includes autism, pervasive developmental disorder (PDD), and Asperger's syndrome. The investigators hope that information gained from this study will lead to new ways of diagnosing and treating ASDs.
| Condition |
|---|
|
Autism Spectrum Disorder Autism Asperger's Syndrome Pervasive Developmental Disorder |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Cross-Sectional |
| Official Title: | Genetic Contributions to Autism Spectrum Disorders |
- Gene expression levels [ Time Frame: At sample collection ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Whole blood, DNA and RNA and/or Saliva, DNA
| Estimated Enrollment: | 1500 |
| Study Start Date: | April 2007 |
| Estimated Study Completion Date: | December 2015 |
| Estimated Primary Completion Date: | December 2015 (Final data collection date for primary outcome measure) |
Participation generally takes less than 2 hours to complete and travel to Children's Hospital Boston is not required. Participants are asked some questions about their medical and family history. The investigators also request permission to review medical records related to the ASD diagnosis. Finally, the investigators obtain a small blood or saliva sample in order to search for genes that may be important in understanding ASD. The investigators can arrange for the blood draw through a participant's physician or a clinical laboratory and saliva samples can be obtained through the mail. The study questions are answered via telephone or mailed questionnaires. There is no cost to participate.
Eligibility| Ages Eligible for Study: | 18 Months and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Children with a diagnosis of an Autism Spectrum Disorder (autism, pervasive developmental disorder (PDD), or Asperger's syndrome) and their parents and/or siblings
Inclusion Criteria:
- Clinical diagnosis of an Autism Spectrum Disorder (autism, pervasive developmental disorder (PDD), or Asperger's syndrome)
- Age > 18 months
Contacts and Locations| United States, Massachusetts | |
| Children's Hospital Boston | |
| Boston, Massachusetts, United States, 02115 | |
| Principal Investigator: | Ingrid A Holm, MD, MPH | Children's Hospital Boston |
More Information
Additional Information:
No publications provided
| Responsible Party: | Children's Hospital Boston |
| ClinicalTrials.gov Identifier: | NCT01160783 History of Changes |
| Other Study ID Numbers: | 07-04-0136 |
| Study First Received: | July 9, 2010 |
| Last Updated: | February 11, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Children's Hospital Boston:
|
Autism Asperger's Syndrome Asperger Syndrome Autistic Disorder Autism Spectrum Disorder |
Pervasive Developmental Disorders PDD-NOS Child Development Disorders, Pervasive Pervasive Developmental Disorder-Not Otherwise Specified |
Additional relevant MeSH terms:
|
Autistic Disorder Developmental Disabilities Asperger Syndrome |
Child Development Disorders, Pervasive Mental Disorders Diagnosed in Childhood Mental Disorders |
ClinicalTrials.gov processed this record on May 16, 2013