RETRIeVE: ReversE TranscRiptase Inhibitor hiV Practice
This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Dr. Mark Bloch, Holdsworth House Medical Practice
First received: June 30, 2010
Last updated: September 8, 2013
Last verified: September 2013
An observational retrospective study of NNRTI experienced patients who have virologically failed. The study aims to assess resistance profiling and subsequent prescription patterns of patients on NNRTIs
||Time Perspective: Retrospective
||Non-nucleoside Reverse Transcriptase Inhibitor Failure in a High HIV Caseload Australian Primary Care Practice
Primary Outcome Measures:
- resistance profiling and subsequent prescription patterns of patients on NNRTIs [ Time Frame: 1 year ] [ Designated as safety issue: No ]
| Estimated Enrollment:
| Study Start Date:
| Primary Completion Date:
||September 2011 (Final data collection date for primary outcome measure)
HIV1 positive, NNRTI exposure and failure
This is a cross-sectional study involving retrospective review of HIV-1 positive patient records who began treatment with a non-nucleoside reverse transcriptase inhibitor (NNRTI) and subsequently failed. Patients who have virologically failed previous NNRTI treatment, or have resistance to 1 drug in the NNRTI class are examined further. Such patients will have attended the clinic every 3-6 months for routine medical care. The data source for variables collected is the patient's electronic medical records. This database is located at Holdsworth House Medical Practice (HHMP), Sydney.
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Demographic information will be collected from patient medical records for all patients that have used previously, or are currently using an NNRTI as part of HIV treatment therapy.
- Documented HIV infection
- Attended Holdsworth House Medical Practice 1999-2009.
- Chosen ART regime includes an NNRTI
Exclusion Criteria: N/A
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01154556
|Holdsworth House Medical Practice
|Darlinghurst, New South Wales, Australia, 2010 |
Holdsworth House Medical Practice
No publications provided
||Dr. Mark Bloch, Principal Investigator, Holdsworth House Medical Practice
History of Changes
|Other Study ID Numbers:
|Study First Received:
||June 30, 2010
||September 8, 2013
||Australia: Human Research Ethics Committee
Keywords provided by Holdsworth House Medical Practice:
Antiretroviral therapy experienced
failed NNRTI regime
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on November 25, 2014
Immune System Diseases
Immunologic Deficiency Syndromes
RNA Virus Infections
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Viral
Reverse Transcriptase Inhibitors
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors