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Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

This study has been completed.
Sponsor:
Information provided by:
Korea University
ClinicalTrials.gov Identifier:
NCT01150019
First received: June 9, 2010
Last updated: July 7, 2010
Last verified: April 2010
History of Changes
  Purpose

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.


Condition Intervention
Atherosclerosis
 Other: Cross sectional study

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Korea University:

Primary Outcome Measures:
  • Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Circulating serum adiponectin levels [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
  • carotid intima-media thickness levels measured using ultrasonography [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
  • Circulating serum resistin levels [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Plasma, whole blood, serum


Enrollment: 120
Study Start Date: April 2010
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Obese Group Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting
Non Obese Group Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy participats who underwent a medical health check in the health promotion center in Korea Guro University

Criteria

Inclusion Criteria:

  • Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • Diabetes
  • Hypertension
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01150019

Locations
Korea, Republic of
Hae Yoon Choi
Seoul, Korea, Republic of, 152-703
Sponsors and Collaborators
Korea University
Investigators
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

No publications provided

Responsible Party: Kyung Mook Choi, Korea University
ClinicalTrials.gov Identifier: NCT01150019     History of Changes
Other Study ID Numbers: PET_Resistin
Study First Received: June 9, 2010
Last Updated: July 7, 2010
Health Authority: South Korea: Institutional Review Board

Keywords provided by Korea University:
atherosclerosis
vascular inflammation
resistin
adiponectin
18FDG-PET

Additional relevant MeSH terms:
Atherosclerosis
Inflammation
Arteriosclerosis
Arterial Occlusive Diseases
 Vascular Diseases
Cardiovascular Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on June 18, 2013