Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Recruitment status was Active, not recruiting
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to Fanconi anemia in patients with acute myeloid leukemia.
PURPOSE: This research study is studying identification of de novo Fanconi anemia in younger patients with newly diagnosed acute myeloid leukemia.
Genetic: western blotting
Other: laboratory biomarker analysis
|Official Title:||Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots|
- Identification of children at high risk of having Fanconi anemia [ Designated as safety issue: No ]
- Identification of Fanconi anemia patients [ Designated as safety issue: No ]
|Study Start Date:||October 2009|
|Estimated Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
- Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961 and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.
- Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi anemia patients using western blot techniques.
OUTLINE: Previously collected cryopreserved cells are analyzed via western blot to identify patients with Fanconi anemia.
|Principal Investigator:||Monica S. Thakar, MD||Fred Hutchinson Cancer Research Center|