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Dietary Interventions for Muscle Mass

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01145131
First received: June 15, 2010
Last updated: September 13, 2011
Last verified: September 2011
History of Changes
  Purpose

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.


Condition Intervention
Aging
 Other: Intact or minced beef meat

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Dietary Interventions for Muscle Mass

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle protein synthesis [ Time Frame: 6 h postprandial period ] [ Designated as safety issue: No ]
    Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound D5phe tracer, by the enrichment of the precursor (=plasma availability).


Secondary Outcome Measures:
  • Dietary amino acid plasma availability [ Time Frame: 6h postprandial period ] [ Designated as safety issue: No ]
    The exogenous rate of phenylalanine appearance will be used to assess the bio-availability of dietary-protein derived amino acids in the circulation during the 6h postprandial period following meat intake


Enrollment: 12
Study Start Date: May 2011
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Beef steak Other: Intact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Other Names:
  • Beef steak
  • Minced beef
  • Beef patty
  • Steak
  • Hamburger
  • Ground beef
Experimental: Minced beef Other: Intact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.
Other Names:
  • Beef steak
  • Minced beef
  • Beef patty
  • Steak
  • Hamburger
  • Ground beef

  Eligibility

Ages Eligible for Study:   65 Years to 85 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Non-obese male subjects (BMI<30) between the age of 65-85 years.

Exclusion Criteria:

  • Type II diabetes or other known diseases, use of medication, female, other ages or BMI than indicated above, participation in any regular exercise program.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01145131

Locations
Netherlands
Universiteit Maastricht, Bewegingswetenschappen
Maastricht, Limburg, Netherlands, 6229ER
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: B Pennings, Ir Maastricht University Medical Center
  More Information

Additional Information:
Information about research performed by the Maastricht Muscle Metabolism group at MUMC  This link exits the ClinicalTrials.gov site

Publications:

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01145131     History of Changes
Other Study ID Numbers: MEC 10-3-065
Study First Received: June 15, 2010
Last Updated: September 13, 2011
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:
muscle
FSR
protein
meat

ClinicalTrials.gov processed this record on June 18, 2013